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Vitamin K-1 Oral Capsules

This page contains information on Vitamin K-1 Oral Capsules for veterinary use.
The information provided typically includes the following:
  • Vitamin K-1 Oral Capsules Indications
  • Warnings and cautions for Vitamin K-1 Oral Capsules
  • Direction and dosage information for Vitamin K-1 Oral Capsules

Vitamin K-1 Oral Capsules

This treatment applies to the following species:
Manufacturer: RXV

Each capsule contains 25 mg of Phytonadione


VITAMIN K-1 Capsules contain phytonadione with excipients in an artificially colored soft gelatin shell.


VITAMIN K-1 Capsules for oral administration possesses the same type and degree of activity as naturally occurring vitamin K. The primary function of vitamin K is to stimulate the production via the liver of active prothrombin from a precursor protein. The mechanism by which vitamin K promotes formation of prothrombin at the molecular level has not been established.

Vitamin K-1 Oral Capsules Indications:

VITAMIN K-1 Capsules are indicated in dogs and cats to counter hypoprothrombinemia induced by ingestion of coumarin-based compounds, common ingredients of commercial rodenticides, and other drug induced hypoprothrombinemia where it has been definitely shown that the result is due to interference with vitamin K metabolism, e.g. salicylates.

NOTE: Regular determinations of prothrombin time response should be performed to guide in the initial and subsequent administration of VITAMIN K-1 oral capsules. The dosage should be adjusted accordingly.


Hypersensitivity to any component of this medication.


It is recommended that VITAMIN K-1 oral capsules be used in follow-up therapy only after the administration of Vitamin K-1 Injection and hospitalization are no longer required. An immediate coagulant effect should not be expected after administration of phytonadione when administered orally.

Phytonadione will not counteract the anticoagulant action of heparin.

Repeated large doses of VITAMIN K-1 are not warranted in hepatic disease if the response to the initial therapy is unsatisfactory. Failure to respond to VITAMIN K-1 may indicate that the condition being treated is inherently unresponsive to VITAMIN K-1.


Protect from light at all times. Temporary resistance to prothrombin-depressing anticoagulants may result, especially when larger doses of phytonadione are used.

Vitamin K-1 Oral Capsules Dosage And Administration:

Dogs and Cats

Hypoprothrombinemia (with hemorrhage) - Administer orally at the rate of 2.5-5 mg/kg body weight (1 capsule per each 22 pounds of body weight for lower dosage or 1 capsule per each 11 pounds of body weight for higher dosage) daily as conditions require up to 3 weeks. Frequency and amount of oral administration should be guided by regular determination of prothrombin time.

The smallest effective dose should be sought to minimize the risk of adverse reactions.

Vitamin K-1 Oral Capsules Caution

VITAMIN K-1 oral capsules are sold only to licensed veterinarians.

How Supplied

VITAMIN K-1 oral capsules are available in bottles of 50 capsules each.




Iss. 01-01

Manufactured for RXVeterinary, Westlake, TX 76262

NAC No.: 10910371

822 7TH STREET, SUITE 605, GREELEY, CO, 80631
Telephone:   817-859-3000
Every effort has been made to ensure the accuracy of the Vitamin K-1 Oral Capsules information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2019 Animalytix LLC. Updated: 2019-02-25