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Polyprenyl Immunostimulant

This page contains information on Polyprenyl Immunostimulant for veterinary use.
The information provided typically includes the following:
  • Polyprenyl Immunostimulant Indications
  • Warnings and cautions for Polyprenyl Immunostimulant
  • Direction and dosage information for Polyprenyl Immunostimulant

Polyprenyl Immunostimulant

This treatment applies to the following species:
Company: VetImmune

US Vet License No. 637

This product license is conditional.

Potency test studies are in progress


Polyprenyl Immunostimulant is a 2 mg/ml solution of phosphorylated polyprenols of the following structure:

where 3 = number of isoprene units in trans-, 7-9 = number of isoprene units in cis - configurations; 1-2 = number of phosphoric anions

Polyprenyl Immunostimulant Indications

The product is an aid in reduction of severity of clinical signs resulting from feline herpesvirus infection in cats 8 weeks of age or older.


Polyprenyl Immunostimulant is administered orally; a single dose equals 0.25 ml/kg. Two oral doses of Polyprenyl Immunostimulant should be administered daily for 15 days.


Forty 10 to 11 week old, specific pathogen-free cats of both sexes were enrolled into placebo-controlled, randomized, double-blinded virus challenge study. The cats were challenged with feline herpesvirus (FeHV-1; rhinotracheitis virus strain SGE). Twenty randomly selected animals (experimental group) received 0.25 ml/kg (0.5mg/kg) of Polyprenyl Immunostimulant orally twice daily on days 0 through 14 days post-challenge (DPC); the other twenty cats (placebo group) received equal amount of placebo solution. The cats were examined for clinical signs daily for 15 DPC, and clinical scores were recorded. All cats enrolled in the study tolerated the administration well, no adverse effects were noted. No toxicity was observed with the substance.

All cats in the study developed disease-defining signs of rhinotracheitis, e.g. rhinitis and conjunctivitis. The severity of the disease was evaluated using clinical scores for each animal, where 0 denotes a lack of sign, 1 - moderate severity, serous discharge, and 2 - high severity, mucopurulent discharge. The animals in the experimental group, treated with Polyprenyl Immunostimulant exhibited significantly lower severity of signs (CI 0.05). Polyprenyl Immunostimulant has adequately demonstrated the ability to reduce the severity of clinical signs in cats 8 weeks of age or older resulting from disease caused by feline herpesvirus.


In the toxicity test with the administration of 5 mg/kg (10x experimental) dose of Polyprenyl Immunostimulant to five cats no signs of systemic illness were noted. All cats tolerated the administration well, were normal on physical examination next day. Safety studies in 390 cats showed that oral application of 0.5 mg/kg Polyprenyl Immunostimulant twice daily for 15 days is safe for cats at or above 8 weeks of age. Fewer than 2% of cats may dislike the taste or develop diarrhea.


Polyprenyl Immunostimulant is shipped in individual vials of 10 ml or in packages of 6 vials. Polyprenyl Immunostimulant is stable for at least 12 months. Should be stored in dark at temperatures above freezing, recommended between 1 - 30 °C. Refrigeration after opening is recommended. Must not be frozen: freezing and thawing may cause precipitation of the product from the solution.

Manufactured by: Sass & Sass, Inc., 115A Flint Rd., Oak Ridge, TN 37830

Distributed by: VetImmune, LLC, P.O. Box 205, Kingston, TN 37763

CPN: 1819000.1

P.O. BOX 205, KINGSTON, TN, 37763
Telephone:   209-600-7070
Fax:   865-940-0042
Every effort has been made to ensure the accuracy of the Polyprenyl Immunostimulant information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2020 Animalytix LLC. Updated: 2020-10-21