Dasuquin

A New Breed of Joint Health Supplement™

What is Dasuquin?

Dasuquin from Nutramax Laboratories, Inc. is a joint health supplement for dogs that goes beyond standard glucosamine supplements. It contains NMX1000™* avocado/soybean unsaponifiables (ASU), decaffeinated tea polyphenols, FCHG49^®* glucosamine hydrochloride, and TRH122^®* low molecular weight chondroitin sulfate in a tasty chewable tablet. It is the most complete joint support supplement available. Dasuquin is available in a formula with and without MSM (methylsulfonylmethane). Your veterinarian has recommended the formula that is best suited for your pet.

What role do the glucosamine hydrochloride and low molecular weight chondroitin sulfate play?

The combination of the trademarked FCHG49 glucosamine hydrochloride and TRH122 low molecular weight chondroitin sulfate supports cartilage production and inhibits enzymes in the joints that break down cartilage. These ingredients together have been shown to protect joint cartilage better than either ingredient alone. A greater than additive effect, known as a “synergistic” effect, on cartilage cells was seen using glucosamine and low molecular weight chondroitin sulfate together.

What is ASU?

ASU stands for avocado/soybean unsaponifiables, an ingredient concentrated directly from avocados and soybeans that is used for joint health. ASU has been shown to improve joint function and comfort levels. Studies using cartilage cells have shown that ASU lowers the expression or production of several compounds involved in the process of cartilage breakdown in joints. ASU complements the positive effects of the other active ingredients in Dasuquin. The glucosamine in Dasuquin is synergistic with low molecular weight chondroitin sulfate and has been shown in cartilage cell studies to be synergistic with ASU. Having ASU in the Dasuquin formula is also beneficial as NMX1000 avocado/soybean unsaponifiables, FCHG49 glucosamine hydrochloride and TRH122 low molecular weight chondroitin sulfate together were shown in cell studies to be more effective than the combination of glucosamine and chondroitin sulfate alone at inhibiting expression of several agents involved in the breakdown of cartilage.

The tea polyphenols are compounds shown to have a positive effect on the cartilage matrix and cartilage cells. These polyphenols also help protect against adverse effects caused by highly charged oxygen compounds, called “free radicals”, throughout the body. Additionally, the compounds may have beneficial effects on weight control, which is important as excess weight increases stress on joint cartilage.

Are there any safety concerns?

While sensitivity to avocados has been reported in a few dogs, taking Dasuquin tablets is not the same as eating whole avocados. The ASU in Dasuquin has been evaluated in a safety study in dogs, and no adverse effects were noted from administration. There are no known contraindications or known interactions between Dasuquin and any drug or nutritional supplement.

What strengths and sizes is Dasuquin available in?

Dasuquin is available in two different strengths because one size doesn't fit all dogs. Dasuquin for Small to Medium Dogs has been optimized for dogs under 60 pounds. Dasuquin for Large Dogs contains a formula optimized for dogs 60 pounds and over. Both formulations are packaged in 84 count and 150 count bottles. The 84 count size is a convenient size for use during the initial 4-6 week loading period, while the 150 count economy size is more cost-effective and is ideal for long-term use.

How is Dasuquin administered?

Dasuquin's tasty chewable tablets can be given as a treat or crumbled and mixed with the food according to the administration tables below.

Dasuquin for Small to Medium Dogs - For dogs under 60 lbs. - INITIAL ADMINISTRATION

Dasuquin for Large Dogs - For dogs 60 lbs. and over - INITIAL ADMINISTRATION

Allow 4-6 weeks initially to note a response, though some dogs may respond sooner. Once a response is seen, the number of tablets may be reduced to the level that keeps your pet comfortable. When lowering the number of tablets, observe your dog closely. If your dog's comfort level appears to decrease, the initial administration amount should be resumed for an additional 2-4 weeks before trying a maintenance level again. Once consistent improvement at the maintenance level has been seen, administration may be further reduced to every other day. An individual dog's needs may vary. Dogs on a maintenance level can be increased back to the initial level at any time as needed, e.g., on weekends or other times when they are more active, to provide extra support to the joints.

A maintenance level can also be used long-term on normal dogs to help keep their joints healthy. At any time, the number of tablets may be increased if needed.

What should I look for when giving Dasuquin?

Observe your dog closely, and notice whether your dog seems more comfortable doing those activities he/she seemed reluctant doing or had some trouble doing previously, such as climbing stairs, jumping in the car, or rising from a down position. Changes in your dog's comfort level may occur gradually. Allow time for your dog to respond. It may take 4-6 weeks, though some dogs may respond sooner.

Is Dasuquin available over-the-counter?

No, Dasuquin is a veterinary-exclusive formula. This formulation is not found over-the-counter in health food stores or pharmacies. As your pet's health care professional, your veterinarian is best qualified to decide if Dasuquin may benefit your dog and can monitor your pet's response, making any adjustments necessary to the administration level.

U.S. Patent Nos. 5,587,363 and 6,797,289

Additional Patent Pending

NUTRAMAX LABORATORIES, INC., 2208 Lakeside Boulevard, Edgewood, Maryland 21040

1-800-925-5187

dasuquin.com

*Dasuquin™ contains FCHG49^® Glucosamine Hydrochloride, TRH122^® Low Molecular Weight Sodium Chondroitin Sulfate, and NMX1000™ Avocado/Soybean Unsaponifiables, Nutramax Laboratories^® veterinary-exclusive proprietary researched specifications.

02-1012-01

Nac No.