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Quadramet Side Effects

Generic name: samarium sm 153 lexidronam

Medically reviewed by Last updated on May 11, 2022.

Note: This document contains side effect information about samarium sm 153 lexidronam. Some of the dosage forms listed on this page may not apply to the brand name Quadramet.

Applies to samarium sm 153 lexidronam: intravenous solution

Side effects requiring immediate medical attention

Along with its needed effects, samarium sm 153 lexidronam (the active ingredient contained in Quadramet) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking samarium sm 153 lexidronam:

More common

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • chest pain
  • chills
  • cough
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • fever
  • hoarseness
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on the skin
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • worsening of pain, temporary

Less common

  • Bloody nose
  • blurred vision
  • confusion
  • cough producing mucus
  • difficulty breathing
  • difficulty in speaking
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • double vision
  • headache
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • large, flat, blue or purplish patches in the skin
  • nervousness
  • pain or swelling in the arms or legs without any injury
  • pounding in the ears
  • problems with bleeding or clotting
  • slow speech
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • tightness in the chest


  • Arm, back, or jaw pain
  • chest discomfort
  • decreased urine output
  • dilated neck veins
  • extreme weakness or tiredness
  • irregular breathing
  • nausea
  • swelling of the face, fingers, feet, or lower legs
  • weight gain

Side effects not requiring immediate medical attention

Some side effects of samarium sm 153 lexidronam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • loss of strength or energy
  • muscle pain or weakness
  • stomach pain
  • vomiting

Less common

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


  • Loss or thinning of hair

More about Quadramet (samarium sm 153 lexidronam)

Patient resources

Professional resources

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.