Skip to main content

Paptase Side Effects

Generic name: papain / urea topical

Note: This document contains side effect information about papain / urea topical. Some of the dosage forms listed on this page may not apply to the brand name Paptase.

Applies to papain / urea topical: topical foam, topical ointment, topical spray


Skin irritation is rarely caused by the exudate resulting from the enzymatic digestion. More frequent dressing changes may alleviate this discomfort until the exudate decreases.[Ref]

Local side effects have rarely included a transient burning sensation and skin irritation.[Ref]


1. "Product Information. Accuzyme (papain-urea topical)." Healthpoint, Fort Worth, TX.

2. "Product Information. Ethezyme (papain-urea topical)." Ethex Corporation, Saint Louis, MO.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.