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Kovia 6.5 Side Effects

Generic name: papain/urea topical

Note: This document contains side effect information about papain/urea topical. Some dosage forms listed on this page may not apply to the brand name Kovia 6.5.

Applies to papain/urea topical: topical foam, topical ointment, topical spray.


Wash your hands before and after applying papain-urea topical.

Clean the wound as directed by your doctor. Use only the type of cleanser your doctor has recommended.

Apply papain-urea topical directly to the wound. Then cover the treated area with bandaging or other dressing recommended by your doctor. Keep the wound covered at all times, because this medication will cause the dead tissues to slough and peel off.

Avoid using hydrogen peroxide to clean your wound before applying papain-urea topical. Hydrogen peroxide can make the papain-urea less effective in breaking down the tissues of your wound.

Do not use other medicated skin products unless your doctor has told you to.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may be more likely to occur, such as mild stinging or burning of the skin where the medicine is applied.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For Healthcare Professionals

Applies to papain/urea topical: topical foam, topical ointment, topical spray.


Local side effects have rarely included a transient burning sensation and skin irritation.[Ref]

Skin irritation is rarely caused by the exudate resulting from the enzymatic digestion. More frequent dressing changes may alleviate this discomfort until the exudate decreases.[Ref]


1. (2004) "Product Information. Accuzyme (papain-urea topical)." Healthpoint

2. (2005) "Product Information. Ethezyme (papain-urea topical)." Ethex Corporation

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.