Lactated Ringers: Package Insert / Prescribing Info
Package insert / product label
Generic name: sodium chloride, sodium lactate, potassium chloride, calcium chloride
Dosage form: injection, solution
Drug class: Sterile irrigating solutions
Medically reviewed by Drugs.com. Last updated on Jun 9, 2025.
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SODIUM LACTATE RINGER'S INJECTION, USP BAG
Sodium Lactate Ringer's Injection Instructions
Please read the instructions carefully and use under the guidance of a physician.
Check carefully before use. Do not use if leakage is found, the drug liquid is unclear, or there are visible particles.
Lactated Ringers Description
This product is a compound preparation, its components are: sodium lactate 3.10g, sodium chloride 6.00g, potassium chloride 0.30g, calcium chloride (CaCl2·2H2O) 0.2g per 1000ml.
Excipient Name: Sodium Hydroxide
Osmotic Pressure Molar Concentration: 240-270mOsmol/kg
Indications and Usage for Lactated Ringers
Regulating body fluids, electrolytes and acid-base balance regulating drugs. For metabolic acidosis or dehydration cases with metabolic acidosis.
Lactated Ringers Description
- 500ml
- 1000ml: Sodium lactate 3.10g, sodium chloride 6.00g, potassium chloride 0.30g, calcium chloride 0.20g.
Lactated Ringers Dosage and Administration
Intravenous drip. Adult 500ml ~ 1000ml at a time, according to age weight and symptoms can be appropriate to increase or decrease. Administration speed: 300 ~ 500ml per hour for adults.
Adverse Reactions/Side Effects
- Patients with hypocalcemia (such as uremia) are prone to numbness, pain, twitching, dyspnea and other symptoms after correcting acidosis, which are often caused by the decrease of calcium ion concentration in the blood;
- Accelerated heart rate, chest tightness, shortness of breath and other pulmonary edema, heart failure;
- Elevated blood pressure;
- Weight gain, edema;
- Alkalosis occurs when overdose;
- The concentration of blood potassium decreases, and sometimes hypokalemia appears.
Related/similar drugs
Contraindications
The following conditions should be contraindicated:
- Heart failure and acute pulmonary edema;
- Cerebral edema;
- Lactic acidosis;
- Severe hepatic insufficiency;
- Severe renal failure oliguria or anuria;
- Hyperkalemia;
- Severe burn;
- Addison's disease.
Precautions
The following cases should be used with caution:
- Diabetic patients taking biguanides (especially hypoglycemic), hinder the liver's utilization of lactic acid, easy to cause lactic acid poisoning;
- Edema patients with a tendency to sodium retention;
- Hypertension patients can increase blood pressure;
- Heart dysfunction;
- The rate of lactic acid degradation is slowed down when liver function is not complete, so as to delay the correction speed of acidosis;
- Hypoxia and shock, insufficient tissue blood supply and hypoxia when lactic acid oxidation into pyruvate into tricarboxylic acid cycle metabolism slowed down, so as to delay the correction speed of acidosis;
- Alcoholism, salicylic acid poisoning, type I glycogen deposition disease have lactic acidosis tendency, it is not appropriate to use sodium lactate to correct the acid-base balance;
- When diabetic ketoacidosis acetoacetic acid, β-hydroxybutyric acid and lactic acid are increased, and often accompanied by poor circulation or insufficient blood supply of organs, lactic acid degradation rate is slowed down;
- Renal insufficiency, prone to water and sodium retention, increase cardiovascular load.
The following tests and observations should be made during medication:
- Blood pH and/or carbon dioxide binding force;
- Serum sodium, potassium, calcium, chlorine concentration determination;
- Determination of renal function, including creatinine, urea nitrogen, etc.;
- Blood pressure;
- Cardiopulmonary function status, such as edema, shortness of breath, cyanosis, pulmonary rale, jugular vein filling, hepato-jugular vein regurgitation, venous pressure or central venous pressure measurement as needed;
- Liver insufficiency performance jaundice, change of mind, ascites, etc., applied before and after sodium lactate and in the application process, often observed at any time.
MEDICATION IN PREGNANT WOMEN AND LACTATING WOMEN
Pregnant women with gestational poisoning may aggravate edema, increase blood pressure, should be used with caution.
MEDICATION IN THE ELDERLY
Elderly patients often have hidden cardiac and renal insufficiency, which should be used with caution.
Drug Interactions
When combined with other drugs, pay attention to the incompatibility of drugs (such as macrolide antibiotics, alkaloids, sulfonamides) due to changes in pH and ionic strength. Because this product contains calcium ions, it will precipitate when mixed with blood containing sodium citra
Lactated Ringers - Clinical Pharmacology
This product can regulate body fluid volume and osmotic pressure, and can supplement potassium, sodium, calcium and chloride ions. Among them, sodium lactate is converted into bicarbonate ion in the body to regulate acid-base balance and maintain normal physiological functions; Na+is the most important cation in extracellular fluid, which is the main substance for maintaining constant osmotic pressure and extracellular volume of body fluid. K+is the main intracellular cation, which plays an important role in maintaining normal neuromuscular excitability. As a second messenger in the cell, calcium ion is closely related to many functions in the body. Lactate ions can correct metabolic acidosis and allow potassium ions to enter the cell from blood and extracellular fluid. When the amount of circulating blood and interstitial fluid in the body is reduced, this product can be used as a supplementary regulator of interstitial fluid, and has a corrective effect on electrolyte disturbance and acidosis.
How is Lactated Ringers supplied
- Plastic infusion bag (non-PVC co-extruded film, double hard tube, easy to fold, double valve and double plug). 50ml/ bag, 100ml/ bag, 250ml/ bag, 500ml/ bag, 10O0ml/ bag.
- Plastic infusion bag (non-PVC co-extruded film, double hard tube, easy to fold, double valve double plug, double aseptic packaging). 50ml/ bag, 100ml/ bag, 250ml/ bag, 500ml/ bag, 1000ml/ bag.
VALIDITY
- The product of 50ml,100ml, and 1000ml specifications is valid for 24 months.
- The validity period of 250ml,500ml is 36 months.
OTHER INFORMATION
[Package]
Plastic infusion bag (non-PVC co-extruded film, double hard tube, easy to break apart , double valve and double plug). 500ml/ bag, 1000ml/ bag.
[Validity] 24 months
[Executive standard] Pharmacopoeia of the People's Republic of China (2020, Volume II)
[Pharmaceutical marketing authorization holder] Name: Huaren Pharmaceutical Co., Ltd. Registered Address: No. 187, Zhuzhou Road, Qingdao High-tech Park,China
[Manufacturer]
Enterprise Name: Huaren Pharmaceutical Co., Ltd.
Production Address: No. 187, Zhuzhou Road, Qingdao High-tech Park,China
Zip code: 266101
Tel.: 400-0648885 0532-67709071
Fax: 0532-88702625
Website:http//www.qdhuaren.com
LACTATED RINGER
sodium lactate, sodium chloride, potassium chloride, calcium chloride injection, solution |
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Labeler - Huaren Pharmaceutical Co., Ltd. (547602854) |