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Psyllium / senna Pregnancy and Breastfeeding Warnings

Psyllium / senna is also known as: Perdiem, SennaPrompt

Psyllium / senna Pregnancy Warnings

Senna has not been formally assigned to a pregnancy category by the FDA. Psyllium has not been formally assigned to a pregnancy category by the FDA. One study of sennosides A and B on rats and rabbits during organogenesis reported no evidence of teratogenicity. Animal studies on psyllium have not been reported. There are no controlled data in human pregnancy. The combination of psyllium and senna should only be given during pregnancy when benefit outweighs risk.

See references

Psyllium / senna Breastfeeding Warnings

There are no data on the excretion of psyllium into human milk. Senna is not excreted into human milk. However, senna is a prodrug which is metabolized in vivo to the active sennosides (glucosides of rhein). Rhein is excreted into human milk in very small amounts. No adverse effects have been observed in nursing infants. The American Academy of Pediatrics considers senna to be compatible with breast-feeding.

See references

References for pregnancy information

  1. "Product Information. Metamucil (psyllium)." Procter and Gamble Pharmaceutic, Cincinnati, OH.
  2. "Product Information. Perdiem Overnight Relief (psyllium)" Novartis Pharmaceuticals, East Hanover, NJ.
  3. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  4. Shepard TH. "Catalog of Teratogenic Agents 6th" Baltimore, MD: Johns Hopkins University Press (1989): 574-5

References for breastfeeding information

  1. "Product Information. Perdiem Overnight Relief (psyllium)" Novartis Pharmaceuticals, East Hanover, NJ.
  2. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  3. Shepard TH. "Catalog of Teratogenic Agents 6th" Baltimore, MD: Johns Hopkins University Press (1989): 574-5
  4. Greenhalf JO, Leonard HS "Laxatives in the treatment of constipation in pregnant and breastfeeding mothers." Practitioner 210 (1973): 259-63
  5. Werthmann ME, Kres SV "Quantitative excretion of senokot in human breast milk." Med Ann Dist Columbia 42 (1973): 4-5
  6. "Product Information. Metamucil (psyllium)." Procter and Gamble Pharmaceutic, Cincinnati, OH.
  7. Baldwin WF "Clinical study of senna administration to nursing mothers: assessment of effects on infant bowel habits." Can Med Assoc J 89 (1963): 566-8
  8. Faber P, Strenge-Hesse A "Relavence of rhein excretion into breast milk." Pharmacology 36(suppl 1) (1988): 212-20

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