Estropipate topical Pregnancy and Breastfeeding Warnings
Estropipate topical is also known as: Ogen Vaginal Cream
Estropipate topical Pregnancy Warnings
Estropipate has been assigned to FDA pregnancy category X. There is no indication for the use of estrogens during pregnancy. Estropipate is contraindicated for use during pregnancy. Estrogenic agents have been associated with urogenital abnormalities in offspring that manifest later in life. Vaginal adenosis, squamous cell dysplasia of the uterine cervix and vaginal cancer have developed later in life in female offspring. In the male offspring, the risks of urogenital abnormalities and testicular cancer later in life are increased.
Estropipate topical Breastfeeding Warnings
There are no data on the excretion of estropipate into human milk. Other estrogens are distributed into breast milk. Estrogens administered to nursing women have been shown to decrease the quantity and quality of breast milk.
References for pregnancy information
- Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
- "Product Information. Ortho-Est (estropipate)." Ortho McNeil Pharmaceutical, Raritan, NJ.
References for breastfeeding information
- Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50