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Estradiol / medroxyprogesterone Pregnancy and Breastfeeding Warnings

Brand names: Lunelle

Estradiol / medroxyprogesterone Pregnancy Warnings

Estradiol-medroxyprogesterone injection has been assigned to pregnancy category X by the FDA. Although some reports have suggested that oral contraceptive hormones may cause a variety of congenital malformations, recent studies (including a meta-analysis of prospective studies) have suggested that an association between oral contraceptive use and congenital malformations does not exist. Some progestins may cause masculinization of female infants. There is no indication for the use of estradiol-medroxyprogesterone injection during pregnancy. Estradiol-medroxyprogesterone injection is contraindicated for use during pregnancy.

See references

Estradiol / medroxyprogesterone Breastfeeding Warnings

There are no data on the excretion of estradiol-medroxyprogesterone injection into human milk. Both the estrogens and progestins occurring in commercially available oral contraceptive formulations are excreted into human milk in very small amounts. The American Academy of Pediatrics considers use of oral contraceptive combinations to be compatible with breast-feeding despite rare reports of breast enlargement in the nursing infant and the possibility of a decrease in milk production and protein content.

See references

References for pregnancy information

  1. Bracken MB. Oral contraception and congenital malformations in offspring: a review and meta-analysis of the prospective studies. Obstet Gynecol. 1990;76:552-7.
  2. Profumo R, Toce S, Kotagal S. Neonatal choreoathetosis following prenatal exposure to oral contraceptives. Pediatrics. 1990;86:648-9.
  3. Janerich DT, Piper JM, Glebatis DM. Hormones and limb-reduction deformities. Lancet. 1973;2:96-7.
  4. Czeizel AE, Kodaj I. A changing pattern in the association of oral contraceptives and the different groups of congenital limb deficiencies. Contraception. 1995;51:19-24.
  5. Product Information. Lunelle (estradiol-medroxyprogesterone). Pharmacia and Upjohn. 2001.

References for breastfeeding information

  1. Committee on Drugs, 1992 to 1993. The transfer of drugs and other chemicals into human milk. Pediatrics. 1994;93:137-50.
  2. McCann MF, Moggia AV, Higgins JE, Potts M, Becker C. The effects of a progestin-only oral contraceptive (levonorgestrel 0.03 mg) on breast-feeding. Contraception. 1989;40:635-48.
  3. Canto TE, Vera L, Polanco LE, Colven CE. Mini-pill in lactating women. Contraception. 1989;39:589-601.
  4. Product Information. Lunelle (estradiol-medroxyprogesterone). Pharmacia and Upjohn. 2001.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.