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Medically reviewed by Last updated on Aug 30, 2023.


(pol ee yoor EE a URE e thane)

Index Terms

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, topical:

Nuvail™: 16% (15 mL)

Brand Names: U.S.

Pharmacologic Category


Biocompatible, polymeric solution; forms uniform film that protects nail from abrasion, friction, and moisture

Use: Labeled Indications

Nail dystrophy: Management of signs and symptoms of nail dystrophy such as nail splitting and nail fragility for intact or damaged nails.


Use with deep, open, or profusely bleeding wounds

Dosing: Adult

Nail dystrophy: Topical: Apply once daily before bedtime to affected nail(s)

Dosing: Geriatric

Refer to adult dosing.


Apply evenly to affected nail plate, proximal and lateral folds, and distal tip; allow to dry completely. Clean affected nails with nail polish remover once weekly. Use of other topical products before application of poly-ureaurethane may prevent film formation and reduce effectiveness. To avoid staining, avoid contact with finished surfaces (eg, furniture, counter tops).


Store at 15°C to 30°C (59°F to 86°F); avoid excessive heat and humidity. Flammable liquid; keep away from heat and flame; use in well-ventilated area.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined: Dermatologic: Skin irritation, stinging of the skin


Concerns related to adverse effects:

• Skin irritation: May sting upon application; discontinue use if redness or other signs of irritation occur.

Special populations:

• Isocyanate sensitization: Patients sensitized to isocyanate should not use poly-ureaurethane.

Other warnings/precautions:

• Flammable: Formulation is flammable; do not expose to high temperatures or near open flame. Use in a well-ventilated area.

More about poly-ureaurethane topical

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.