Medically reviewed by Drugs.com. Last updated on Mar 3, 2019.
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- Gentamicin Sulfate
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Gentak: 0.3% (3.5 g) [contains methylparaben, propylparaben]
Generic: 0.3% (3.5 g [DSC])
Generic: 0.3% (5 mL, 15 mL [DSC])
Brand Names: U.S.
- Antibiotic, Aminoglycoside
- Antibiotic, Ophthalmic
Interferes with bacterial protein synthesis by binding to 30S ribosomal subunit resulting in a defective bacterial cell membrane
Ophthalmic drops: Systemic absorption: Undetected (<0.5 mcg/mL)
Use: Labeled Indications
Ophthalmic infections: Topical treatment of ocular bacterial infections, including conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute meibomianitis, and dacryocystitis caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Enterobacter aerogenes, Escherichia coli, Haemophilus influenza, Klebsiella pneumonia, Neisseria gonorrhoeae, Pseudomonas aeruginosa, and Serratia marcescens.
Hypersensitivity to gentamicin or any component of the formulation
Ophthalmic infections: Ophthalmic:
Ointment: Instill 1/2" (1.25 cm) 2 to 3 times daily
Solution: Instill 1 to 2 drops every 4 hours, up to 2 drops every hour for severe infections
Refer to adult dosing.
Ophthalmic infections: Ophthalmic:
Ointment: Instill 1/2 inch (1.25 cm) to affected eye(s) 2 to 3 times/day
Solution: Instill 1 to 2 drops into affected eye(s) every 4 hours; up to 2 drops every hour for severe infections
For topical ophthalmic use only; not for injection into the eye. Avoid contaminating tip of the solution container or ointment tube.
Store at controlled room temperature of 20°C to 25°C (68°F to 77°F).
There are no known significant interactions.
>1%: Ophthalmic: Burning sensation of eyes, eye irritation
<1%, postmarketing, and/or case reports: Corneal ulcer, hallucination, hypersensitivity reaction, purpura, thrombocytopenia
Concerns related to adverse effects:
• Corneal healing: May delay corneal healing.
• Sensitization: Topical use has been associated with local sensitization (redness, irritation); discontinue if sensitization is noted.
• Superinfection: Prolonged use may result in fungal or bacterial superinfection; if purulent discharge, inflammation, or pain are increased, therapy should be re-evaluated.
• Appropriate use: Not for injection into the eye.
• Long-term use: Not intended for long-term therapy.
Pregnancy Risk Factor
Adverse events were observed following systemic administration of gentamicin in animal reproduction studies. The amount of gentamicin available systemically following application of the ophthalmic drops is below the limit of detection (<0.5 mcg/mL) (Trope 1979). In general, if ophthalmic agents are needed in pregnant women, the minimum effective dose should be used in combination with punctual occlusion to decrease systemic absorption (Samples 1988).
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience burning. Have patient report immediately to prescriber vision changes, eye pain, or severe eye irritation (HCAHPS)
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about gentamicin ophthalmic
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Pricing & Coupons
- En Español
- Drug class: ophthalmic anti-infectives
- Gentamicin Sulfate eent (AHFS Monograph)
- Gentamicin Ophthalmic Ointment (FDA)
- Gentamicin Ophthalmic Solution (FDA)