Medically reviewed on February 21, 2018
Scientific Name(s): Artemisia argyi Levl. et Vant. Family: Asteraceae
Common Name(s): Chinese mugwort
Anticancer activity of flavones isolated from Chinese mugwort against several cancer cell lines has been documented in numerous in vitro and animal studies. However, clinical trials are lacking to support use in cancer treatment or prevention.
Chinese mugwort is available commercially in the United States and Europe, but dosing information is limited. Most products are available in powder and oil doseforms. Other products contain herbal mixtures that include Chinese mugwort.
Avoid use if hypersensitivity to any Chinese mugwort components exists. No absolute contraindications have been documented.
Information regarding safety and efficacy in pregnancy and lactation is lacking.
The flavones eupatilin and jaceosidin may potently inhibit drugs metabolized by CYP1A2 (eg, several antidepressants and antipsychotics, some antibiotics) and CYP2C9 (numerous analgesic, antipyretic, anti-inflammatory, antiepileptic, statin, antidiabetic, anticoagulant, anticancer, antifungal, and antibacterial medications).
Information is limited. One study suggests that the proteins in Chinese mugwort may cause severe allergies in hypersensitive individuals.
Information is limited.
The genus Artemisia contains approximately 500 species. A. argyi is an herbaceous perennial plant that typically grows 30 to 50 cm in height and has a main or single taproot system. Chinese mugwort is grayish in color with ovate leaves 5 to 7 cm long and 3 to 5 cm wide. The flowers are pale yellow, and the whole plant is strongly aromatic. The plant is native to China and Japan, prefers dry soil, and has a growth cycle from March to October. 1 , 2 , 3
Since ancient times, Chinese mugwort has been used in several applications. The plant is edible and can be used to make pastries, breads, dumplings, and cakes, and can be mixed with rice or processed into tea or wine. It has also been used as an air purifier and a mosquito repellent. 4
In traditional Chinese medicine, the leaf has been used to treat asthma, malaria, hepatitis, and inflammation, as well as fungal, bacterial, and viral infections. 5 The leaves have been used to treat tuberculosis, menstrual symptoms, and eczema, and are chewed to relieve cough. 6 , 7 Chinese mugwort is used in the traditional Chinese medicine therapy moxibustion to help heat the area being treated in acupuncture. 4 , 8
Eupatilin is a pharmacologically active flavone from Chinese mugwort. 9 A synthetic analog of eupatilin is being evaluated in various phase 1 and 2 trials for treating dry eye and gastritis.
Extensive chemical studies of Artemisia species, including Chinese mugwort, document many compounds, including monoterpenes, sesquiterpenes, triterpenes, and flavones. 10 , 11 , 12 , 13 , 14 Phytochemical databases of Chinese herbal constituents document approximately 106 bioactive compounds in Chinese mugwort. 11 The lactone artemisolide, isolated from the aerial parts of the plant, exhibits antitumor activity. 10 Artemisolides B, C, and D have been isolated and also exhibit similar antitumor activity. 12
Chemical analysis of the plant's flowers revealed 53 volatile constituents, as well as 36 essential oil components in the leaves. 5 , 13 , 14 Four of the essential oil compounds have antiasthmatic activity in rats. Analysis of chemical seasonality showed October as the best time to collect Chinese mugwort leaves.
Uses and Pharmacology
Anticancer activity of flavones isolated from Chinese mugwort has been found against several cancer cell lines in numerous in vitro and animal studies.Cancer
In vitro and animal studies
Growth inhibitory activity is documented for leaf aqueous extracts against a variety of human cancer cell lines, including those in breast, lung, pancreas, and prostate tissues. 15 Apoptotic death of mouse thymocytes was suppressed by a polysaccharide leaf extract that may modulate gene expression. 16 A leaf extract exhibited some inhibitory activity against a neuroblastoma cell line. 17
Arteminolides, isolated from the aerial parts of Chinese mugwort, inhibited tumor cell growth in a dose-dependent manner on human colon adenocarcinoma cells and human lung cells, with no loss in body weight in mice. 18 An ethyl acetate leaf extract containing the coumarin flavones scopoletin and isoscopoletin inhibited leukemia cell growth in a cell proliferation assay. 19 , 20 Additionally, the 2 substances also inhibited growth of a multidrug resistant leukemia cell subline. 19
Jaceosidin, a flavone in several Artemisia species, induced apoptosis in a human ovary adenocarcinoma cell line by activating the mitochondrial pathway. 21 Apoptosis was also induced in human breast epithelial cells by generating free radicals or reactive oxygen species. 22 Jaceosidin inhibited cyclooxygenase-2 (COX-2) and matrix metalloproteinases in cultured human mammary epithelial cells; elevated levels of COX-2 and matrix metalloproteinases are found in numerous cancerous and transformed cells. 23 Interactions between E6 and E7 oncoproteins of the human papillomavirus and tumor suppressors (p53 and pRb), as well as growth of human papillomavirus-harboring cervical cancer cells, were also inhibited by jaceosidin. 16 , 24 This inhibitory activity may be associated with the recovery of p53 and pRb tumor suppressors. Additional studies document similar anticancer activity of other isolated flavones. Some of the inhibition of the flavones is associated with farnesyl protein transferase interference. Oncogenic activity is abolished if farnesyl protein transferase activity is blocked. 25 , 26Other pharmacologic activity
A swimming test in mice administered essential oil for 30 days resulted in reduced lactic acid in the blood and increased elimination of lactic acid. Decreased consumption of glycogen and increased levels of urea nitrogen in serum were also found. 27Antifungal activity
The essential oil extracted from Chinese mugwort exhibited antifungal activity against 2 common storage pathogens of fruits and vegetables, Botrytis cinerea and Alternaria alternata . 28Antioxidant
Although study details are limited, 2 chemical constituents of Chinese mugwort inhibited platelet aggregation. 31Immune system
Jaceosidin inhibited T-cell–mediated contact dermatitis in mice by blocking activation of T lymphocytes leading to reduced swelling and inflammation. 32
Chinese mugwort is available commercially in the United States and Europe, but dosing information is limited. Most products are available in powder and oil doseforms and are used for promoting cardiovascular health as well as for treating asthma or cough. Other products contain herbal mixtures that include Chinese mugwort.
Information regarding safety and efficacy in pregnancy and lactation is lacking.
The flavones eupatilin and jaceosidin may potently inhibit drugs metabolized by CYP1A2 (eg, several antidepressants and antipsychotics, some antibiotic medications) and CYP2C9 (numerous analgesic, antipyretic, anti-inflammatory, antiepileptic, statin, antidiabetic, anticoagulant, anticancer, antifungal, and antibacterial medications). 33
Limited information is available in the medical literature. One study suggests that the proteins in Chinese mugwort may cause severe allergies in hypersensitive individuals. 34
Information is limited. No toxicity was documented on development of forelimb buds and skeletal structure of embryonic mice administered the volatile oil from Chinese mugwort in utero. 35
Bibliography1. Lee MY, Doh EJ, Park CH, et al. Development of SCAR marker for discrimination of Artemisia princeps and A. argyi from other Artemisia herbs. Biol Pharm Bull . 2006;29(4):629-633.
2. Lee MY, Doh EJ, Kim ES, et al. Application of the multiplex PCR method for discrimination of Artemisia iwayomogi from other Artemisia herbs. Biol Pharm Bull . 2008;31(4):685-690.
3. Chen X, Yang YS, Tang JJ. Species-diversified plant cover enhances orchard ecosystem resistance to climatic stress and soil erosion in subtropical hillside. J Zhejiang Univ Sci . 2004;5(10):1191-1198.
4. Li J, Zhao B. Safety concerns about the application of moxa. J Acupunct Tuina Sci . 2010;8(3):145-148.
5. Zheng X, Deng C, Song G, Hu Y. Comparison of essential oil composition of Artemisia argyi leaves at different collection times by headspace solid-phase microextraction and gas chromatography-mass spectrometry. Chromatographia . 2004;59(11/12):729-732.
6. Lan MB, Zhang YH, Zheng Y, Yuan HH, Zhao HL, Gao F. Antioxidant and immunomodulatory activities of polysaccharides from Moxa ( Artemisia argyi ) leaf. Food Sci Biotechnol . 2010;19(6):1463-1469.
7. Samuel AJ, Kalusalingam A, Chellappan DK, et al. Ethnomedical survey of plants used by the Orang Asli in Kampung Bawong, Perak, West Malaysia. J Ethnobiol Ethnomed . 2010;6:5.
8. Adams JD Jr, Garcia C, Lien EJ. A comparison of chinese and american Indian (chumash) medicine. Evid Based Complement Alternat Med . 2010;7(2):219-225.
9. Mishra BB, Tiwari VK. Natural products: an evolving role in future drug discovery. Eur J Med Chem . 2011;46(10):4769-4807.
10. Kim JH, Kim HK, Jeon SB, et al. New sesquiterpene-monoterpene lactone, artemisolide, isolated from Artemisia argyi . Tetrahedron Letters . 2002;43(35):6205-6208.
11. Ehrman TM, Barlow DJ, Hylands PJ. Phytochemical databases of Chinese herbal constituents and bioactive plant compounds with known target specificities. J Chem Inf Model . 2007;47(2):254-263.
12. Lee SH, Kim HK, Seo JM, et al. Arteminolides B, C, and D, new inhibitors of farnesyl protein transferase from Artemisia argyi . J Org Chem . 2002;67(22):7670-7675.
13. Pan JG, Xu ZL, Ji L. Chemical studies on essential oils from 6 Artemisia species [in Chinese]. Zhongguo Zhong Yao Za Zhi . 1992;17(12):741-744, 764.
14. Li N, Mao Y, Deng C, Zhang X. Separation and identification of volatile constituents in Artemisia argyi flowers by GC-MS with SPME and steam distillation. J Chromatogr Sci . 2008;46(5):401-405.
15. Shoemaker M, Hamilton B, Dairkee SH, Cohen I, Campbell MJ. In vitro anticancer activity of twelve Chinese medicinal herbs. Phytother Res . 2005;19(7):649-651.
16. Chung HK, Bae EK, Ji HJ, et al. An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene. Biotechnol Lett . 2003;25(18):1549-1553.
17. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.
18. Lee SH, Lee MY, Kang HM, et al. Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa. Bioorg Med Chem . 2003;11(21):4545-4549.
19. Adams M, Efferth T, Bauer R. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi . Planta Med . 2006;72(9):862-864.
20. McGovern PE, Christofidou-Solomidou M, Wang W, Dukes F, Davidson T, El-Deiry WS. Anticancer activity of botanical compounds in ancient fermented beverages (review). Int J Oncol . 2010;37(1):5-14.
21. Lv W, Sheng X, Chen T, Xu Q, Xie X. Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway. J Biomed Biotechnol . 2008;2008:394802.
22. Kim MJ, Kim DH, Lee KW, Yoon DY, Surh YJ. Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species. Ann N Y Acad Sci . 2007;1095:483-495.
23. Jeong MA, Lee KW, Yoon DY, Lee HJ. Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi , inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. Ann N Y Acad Sci . 2007;1095:458-466.
24. Lee HG, Yu KA, Oh WK, et al. Inhibitory effect of jaceosidin isolated from Artemisia argyi on the function of E6 and E7 oncoproteins of HPV 16. J Ethnopharmacol . 2005;98(3):339-343.
25. Nakasugi T, Nakashima M, Komai K. Antimutagens in gaiyou ( Artemisia argyi levl. et vant.). J Agric Food Chem . 2000;48(8):3256-3266.
26. Seo JM, Kang HM, Son KH, et al. Antitumor activity of flavones isolated from Artemisia argyi . Planta Med . 2003;69(3):218-222.
27. Han J, Anji H, Zhixue X, et al. Anti-fatigue effect of essential oil extracted from Artemisia argyi . Wuhan Daxue Xuebao (Yixue Ban) . 2005;26(3):373-374, 390.
28. Wenqiang G, Shufen L, Ruixiang Y, Yanfeng H. Comparison of composition and antifungal activity of Artemisia argyi Lévl. et Vant inflorescence essential oil extracted by hydrodistillation and supercritical carbon dioxide. Nat Prod Res . 2006;20(11):992-998.
29. Liao H, Banbury LK, Leach DN. Antioxidant activity of 45 Chinese herbs and the relationship with their TCM characteristics. Evid Based Complement Alternat Med . 2008;5(4):429-434.
30. Jung DY, Park SW. Cytotoxicity of water fraction of Artemisia argyi against L1210 cells and antioxidant enzyme activities. Yakhak Hoeji . 2002;46(1):39-46.
31. Zhong Y, Cui S. Effective chemical constituents of Artemisia argyi Levl. et Vant for inhibition of platelet aggregation [in Chinese]. Zhongguo Zhong Yao Za Zhi . 1992;17(6):353-354, 383.
32. Yin Y, Sun Y, Gu L, et al. Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. Eur J Pharmacol . 2011;651(1-3):205-211.
33. Ji HY, Kim SY, Kim DK, Jeong JH, Lee HS. Effects of eupatilin and jaceosidin on cytochrome p450 enzyme activities in human liver microsomes. Molecules . 2010;15(9):6466-6475.
34. Yang H, Liu ZG, Han QG, Hou SB, Liang GZ. Purification and identification of major allergens in Artemisia argyi pollen. Zhonghua Weishengwuxue He Mianyixue Zazhi . 2005;25(1):73-77.
35. Lan MB, Li XH, Jiang HC, Zhang H, Yu YL. Developmental toxicity of volatile oil from Artemisia argyi on skeleton of embryo mice. Zhongguo Yaolixue Yu Dulixue Zazhi . 2010;24(6):521-524.
Copyright © 2009 Wolters Kluwer Health
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.