Meldonium
Maria Sharapova, former world number one tennis player, failed a drug test for Meldonium on January 26, 2016. Meldonium (also known as Mildronate) is manufactured in Latvia and used in the treatment of certain heart conditions. It works by dilating blood vessels and increasing blood flow, which in turn improves exercise capacity, physical and mental endurance, and also brain function.
Meldonium was on the World Anti-Doping Agency’s (WADA) list of drugs being monitored until September 2015, when it was added to the list of banned substances, effective January 1, 2016.
Maria Sharapova had been taking Meldonium since 2006. Her family doctor had prescribed it for her irregular EKGs, magnesium deficiency, and a family history of diabetes. Sharapova claims she was unaware Meldonium had been added to the WADA list of banned substances until receipt of a letter from the International Tennis Federation informing her of a failed drug test during the 2016 Australian Open.
Scheme
Rec.INN
CAS registry number (Chemical Abstracts Service)
0076144-81-5
Chemical Formula
C6-H14-N2-O2
Molecular Weight
146
Therapeutic Categories
Treatment of cardiac disorders
Inhibitor of carnitine synthesis
Chemical Names
3-(2,2,2-Trimetyldiazaniumyl)propanoate (WHO)
3-(2,2,2-Trimetylhydrazinium)propionat (IUPAC)
Foreign Names
- Meldonium (Latin)
- Meldonium (German)
- Meldonium (French)
- Meldonio (Spanish)
Generic Names
- Mildronate (IS)
- Meldonium Dihydrate (PH: BP 2018, Ph. Eur. 9)
Brand Names
- Meldonium Olainfarm
Olainfarm, Latvia - Meldonium-MIK
UP Minskintercaps, Georgia - Mildronat
HBM Pharma, Georgia - Mildronat Grindeks
Grindeks, Latvia - Mildronat Neo
Grindeks, Georgia - Mildronats
Grindeks, Latvia - Mildroxyn
Aversi, Georgia - Saturid
Mefar Ilaç Sanayii, Georgia - Venarin
Remedy Group, Georgia - Cardionate
Makis Pharma, Russian Federation - Idrinol
Sotex, Georgia - Meldonat-Lekpharm
Lekfarm, Georgia - Midromax
EuroMedical, Georgia - Mildronat
Grindeks, Georgia; Santonika, Georgia - Mildronate
Grindeks, Lithuania; Grindex, Russian Federation - Milkor
GMP, Georgia - Ripronat
Mefar Ilaç Sanayii, Georgia; Rompharm, Georgia; World Medicine, Georgia - Riprozin
Rompharm, Georgia - Zovanat
Corpus Medica, Lithuania
Glossary
| Term | Definition |
|---|---|
| IUPAC | International Union of Pure and Applied Chemistry |
| IS | Inofficial Synonym |
| PH | Pharmacopoeia Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| WHO | World Health Organization |
Further information on drug naming conventions: International Nonproprietary Names.
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