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Maria Sharapova, former world number one tennis player, failed a drug test for Meldonium on January 26, 2016. Meldonium (also known as Mildronate) is manufactured in Latvia and used in the treatment of certain heart conditions. It works by dilating blood vessels and increasing blood flow, which in turn improves exercise capacity, physical and mental endurance, and also brain function.

Meldonium was on the World Anti-Doping Agency’s (WADA) list of drugs being monitored until September 2015, when it was added to the list of banned substances, effective January 1, 2016.

Maria Sharapova had been taking Meldonium since 2006. Her family doctor had prescribed it for her irregular EKGs, magnesium deficiency, and a family history of diabetes. Sharapova claims she was unaware Meldonium had been added to the WADA list of banned substances until receipt of a letter from the International Tennis Federation informing her of a failed drug test during the 2016 Australian Open.



CAS registry number (Chemical Abstracts Service)


Chemical Formula


Molecular Weight


Therapeutic Categories

Treatment of cardiac disorders

Inhibitor of carnitine synthesis

Chemical Names

3-(2,2,2-Trimetyldiazaniumyl)propanoate (WHO)

3-(2,2,2-Trimetylhydrazinium)propionat (IUPAC)

Foreign Names

  • Meldonium (Latin)
  • Meldonium (German)
  • Meldonium (French)
  • Meldonio (Spanish)

Generic Names

  • Mildronate (IS)
  • Meldonium Dihydrate (PH: BP 2018, Ph. Eur. 9)

Brand Names

  • Meldonium Olainfarm
    Olainfarm, Latvia
  • Meldonium-MIK
    UP Minskintercaps, Georgia
  • Mildronat
    HBM Pharma, Georgia
  • Mildronat Grindeks
    Grindeks, Latvia
  • Mildronat Neo
    Grindeks, Georgia
  • Mildronats
    Grindeks, Latvia
  • Mildroxyn
    Aversi, Georgia
  • Saturid
    Mefar Ilaç Sanayii, Georgia
  • Venarin
    Remedy Group, Georgia
  • Cardionate
    Makis Pharma, Russian Federation
  • Idrinol
    Sotex, Georgia
  • Meldonat-Lekpharm
    Lekfarm, Georgia
  • Midromax
    EuroMedical, Georgia
  • Mildronat
    Grindeks, Georgia; Santonika, Georgia
  • Mildronate
    Grindeks, Lithuania; Grindex, Russian Federation
  • Milkor
    GMP, Georgia
  • Ripronat
    Mefar Ilaç Sanayii, Georgia; Rompharm, Georgia; World Medicine, Georgia
  • Riprozin
    Rompharm, Georgia
  • Zovanat
    Corpus Medica, Lithuania


IUPACInternational Union of Pure and Applied Chemistry
ISInofficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
WHOWorld Health Organization

Further information on drug naming conventions: International Nonproprietary Names.

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