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Calcium Folinate

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

V03AF03

CAS registry number (Chemical Abstracts Service)

0001492-18-8

Chemical Formula

C20-H21-Ca-N7-O7

Molecular Weight

512

Therapeutic Categories

Antidote against folic acid antagonists

Detoxifying agent for antineoplastic treatment

Chemical Name

Calcium N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)metyl]amino]benzoyl]glutamate (WHO)

Foreign Names

  • Calcii folinas (Latin)
  • Calcium folinat (German)
  • Folinate de calcium (French)
  • Folinato cálcico (Spanish)

Generic Names

  • Calcium Folinate (OS: JAN, BANM)
  • Folinato di calcio (OS: DCIT)
  • (+)-L-Folinic acid, calcium salt (IS)
  • Calcifolin (IS)
  • Calcio folinato (IS)
  • Calcium citrovorum factor (IS)
  • Calfonat (IS)
  • Folinat-SF Calcium (IS)
  • Folinic acid calcium salt (IS)
  • Leucovorin Calcium (IS)
  • Calcii folinas (PH: Ph. Eur. 9, Ph. Int. 7)
  • Calcium Folinate (PH: BP 2018, JP XVII, Ph. Int. 7)
  • Calcium folinate (PH: Ph. Eur. 9)
  • Leucovorin Calcium (PH: USP 41)
  • Folinsäure, Calciumsalz-5-Wasser (IS)
  • NSC 3590 (IS)

Brand Names

  • Ai Jie Kang
    Hua Lu Pharm, China
  • Ai Ru Xi
    Tian Yu Pharmaceutical, China
  • Antrex
    Orion, China; Orion, Taiwan; Orion Pharma, Finland
  • Bendafolin [+ Folinic acid]
    Bendalis, Bulgaria
  • Bendafolin 10mg/ml
    Bendalis, Germany
  • Bicomplex [+ Riboflavin, + Nicotinamide, + Cyanocobalamin, + Thiamine]
    ABC Farmaceutici, Georgia
  • Bloodlet
    Yung Shin, Taiwan
  • Buateron
    Venifar Ltd, Greece
  • Cafona
    Synmosa, Taiwan
  • Cafonate
    Naprod, Philippines; Naprod Life Sciences, Thailand
  • Cafonia
    Yuan Chou, Taiwan
  • Calcifolin
    Ibirn, Italy; Provident Azrneimittel AG, Greece
  • Calcilinat F100
    Binhdinh Pharmaceutical and Medical Equipment Company Bidiphar, Vietnam
  • Calcilinat F50
    Binhdinh Pharmaceutical and Medical Equipment Company Bidiphar, Vietnam
  • Calcio Folinato ESP Pharma
    ESP Pharma, Italy
  • Calcio Folinato Pliva
    BioHealth Pharmaceuticals, Italy
  • Calcium Folinat
    Ebewe, Lebanon
  • Calcium Folinat Ebewe
    Ebewe, Romania; Sandoz, Australia
  • Calcium Folinate
    Bio Pharma, Pakistan; Consilient Health, United Kingdom; Ebewe, Lebanon; Generics UK, United Kingdom; Hospira UK, United Kingdom; Pfizer, Thailand; Rue Belmedpreparaty, Georgia
  • Calcium Folinate - Cuccess Pharm
    Nanjing Cuccess Pharmaceutical, China
  • Calcium Folinate - Wanma Pharm
    Wanma Pharmaceutical, China
  • Calcium folinate Acdima
    Acdima, Egypt
  • Calcium folinate Actavis
    Actavis, Macedonia
  • Calcium folinate Al Masria
    Al Masria, Egypt
  • Calcium folinate Baxter
    Baxter, New Zealand
  • Calcium folinate Dbl
    Dbl, Egypt
  • Calcium Folinate Ebewe
    Ferron/Ebewe, Indonesia; Novartis, New Zealand
  • Calcium folinate Ebewe
    Ebewe, Egypt
  • Calcium Folinate Hospira
    Hospira, Malta
  • Calcium folinate Hospira
    Hospira, Egypt
  • Calcium Folinate Kabi
    Fresenius Kabi, Poland; Fresenius Kabi Deutschland, Malta
  • Calcium Folinate Kocak
    Kocak Farma, Turkey
  • Calcium folinate Merck
    Merck, Egypt
  • Calcium Folinate Sandoz
    Ebewe Pharma, Bulgaria; Novartis, New Zealand; Sandoz, Czech Republic; Sandoz, Lithuania; Sandoz, Poland; Sandoz, Sweden; Sandoz, Slovakia
  • Calcium Folinate Trading
    Pharmaceutical Trading, Cyprus
  • Calcium Folinate-DBL
    Orna, Turkey
  • Calcium Leucovorin
    Wyeth, India
  • Calcium Leucovorin Lederle
    Lederle, Kuwait
  • Calciumfolinat
    Ebewe, Latvia
  • Calciumfolinat Amneal
    Amneal Deutschland, Germany
  • Calciumfolinat aries
    Apocare, Germany
  • Calciumfolinat axios
    Axios, Germany
  • Calciumfolinat Bhardwaj
    Tillomed Pharma, Germany
  • CALCIUMFOLINAT biosyn
    Biosyn, Germany
  • Calciumfolinat Ebewe
    Ebewe, Serbia; Ebewe, Slovakia; Ebewe, Tunisia; Ebewe Pharma, Bulgaria; Ebewe Pharma, Macedonia; Würth, Croatia (Hrvatska)
  • Calciumfolinat Ebewe 10 mg/ml
    Ebewe Pharma, Austria
  • Calciumfolinat Ebewe 15 mg
    Ebewe, Hungary; Ebewe Pharma, Austria
  • Calciumfolinat Ebewe 1omg/ml
    Ebewe, Israel
  • Calciumfolinat Fresenius Kabi
    Fresenius Kabi, Denmark
  • Calciumfolinat Heumann
    Heumann, Germany
  • Calciumfolinat Hospira
    Hospira, Germany; Hospira, Sweden; Hospira Nordic, Denmark
  • Calciumfolinat Kabi
    Fresenius Kabi Deutschland, Germany
  • Calciumfolinat Kabi 10 mg/ml
    Fresenius Kabi, Austria
  • Calciumfolinat Medipolis
    Medipolis Produktion, Germany
  • Calciumfolinat onkovis
    Onkovis, Germany
  • Calciumfolinat Profusio
    PGD Profusio Haan, Germany
  • Calciumfolinat Sandoz 10 mg/ml
    Sandoz, Austria
  • Calciumfolinat Sandoz 15mg
    Sandoz, Switzerland
  • Calciumfolinat Sandoz eco 100mg/10ml
    Sandoz, Switzerland
  • Calciumfolinat Sandoz eco 500mg/50ml
    Sandoz, Switzerland
  • Calciumfolinat Sandoz eco 50mg/5ml
    Sandoz, Switzerland
  • Calciumfolinat Stada 10 mg/ml
    Stada Arzneimittel, Austria
  • Calciumfolinat SUN
    SUN Pharmaceuticals Germany, Germany
  • Calciumfolinat Vipharm
    Vipharm, Germany
  • Calciumfolinate
    Teva, Norway
  • Calciumfolinate Sandoz
    Sandoz, Denmark
  • Calciumfolinate Teva
    Teva, Sweden
  • Calciumfolinat-Ebewe
    Ebewe, Poland; Ebewe, Taiwan; Sandoz, Hong Kong; Sandoz, Thailand
  • Calfolex
    Sirton Medicare, Italy
  • Calfolin
    Johnson, Taiwan
  • Citofolin
    Bracco, Italy
  • Covorin
    Patron, Taiwan
  • Cromatonbic Ferro [+ Cyanocobalamin]
    Menarini, Costa Rica; Menarini, Dominican Republic; Menarini, Guatemala; Menarini, Honduras; Menarini, Nicaragua; Menarini, Panama; Menarini, El Salvador
  • DBL Calcium Folinate
    Hospira Singapore, Singapore
  • DBL Leucovorin Calcium
    Pfizer, Australia; Pfizer, New Zealand
  • Eparmefolin [+ Cyanocobalamin]
    Bracco, Italy
  • Estroquin 15
    Richmond, Paraguay; Richmond, Uruguay
  • Estroquin 50
    Richmond, Paraguay; Richmond, Uruguay
  • Etamolin
    AC Farma, Peru
  • Fauldleuco
    Libbs, Brazil
  • Fedolen
    Viofar, Greece
  • Ferbon
    Samjin, South Korea
  • Ferrofolin [+ Ferric Proteinsuccinylate]
    SIT, Italy
  • Folaren
    Ist.Chim.Intern.Rende, Italy
  • Folcasin
    Actavis, Romania; Actavis D.O.O., Serbia
  • Folidar
    Italfarmaco, Italy
  • Folikabi
    Fresenius Kabi Deutschland GmbH, Netherlands
  • Folina
    TTY Biopharm, Taiwan
  • Folinat de Calciu Kabi
    Fresenius Kabi Deutschland, Romania
  • Folinat de Calciu Teva
    Teva Romania, Romania
  • Folinate de calcium Aguettant
    Aguettant, France; Aguettant, Tunisia
  • Folinate de calcium Sandoz
    Sandoz, France
  • Folinate de calcium Zentiva
    Sanofi-Aventis, France
  • Folinate EG
    Eurogenerics, Belgium
  • Folinate EG 200mg/20ml
    Eurogenerics, Luxembourg
  • Folinate EG 500mg/50ml
    Eurogenerics, Luxembourg
  • Folinato
    Angelini Pharma, Greece
  • Folinato Cálcico
    Perulab, Peru
  • Folinato Calcico G.E.S.
    Ges Genericos, Spain
  • Folinato Calcico Genfarma
    Genfarma, Spain
  • Folinato Calcico Normon
    Normon, Spain
  • Folinato Calcico Sandoz
    Sandoz España, Spain
  • Folinato Calcico Teva
    Teva, Spain
  • Folinato Calcio (Leucovorina Calcia) Pharma Arte
    Pharma Arte, Paraguay
  • Folinato de Calcio
    Vitalis, Peru
  • Folinato de cálcio Hikma
    Hikma Farmacêutica Portugal, Portugal
  • Folinato de cálcio Kabi
    Fresenius Kabi, Portugal
  • Folinato de Cálcio Teva
    Teva Pharma, Portugal
  • Folinato de Calcio Vitalis
    Vitalis, Costa Rica
  • Folinfabra
    Fabra, Argentina
  • Folinic Acid
    FIT-BioCeuticals, Australia; Hospira, Ireland
  • Folinic Mouthwash
    Extemporaneous Product, New Zealand
  • Folinico Acido
    Precimex, Mexico
  • Folinoral
    Thérabel Lucien, France
  • Fu Neng
    Ling Nan Pharmaceutical, China
  • Gai Er Qing
    Ya Bao Pharma Group, China
  • HAEMATO-folin
    HAEMATO PHARM, Germany
  • Hospira Leucovorin Calcium
    Hospira, Philippines
  • Innefol
    Pisa, Mexico
  • Kalcijev folinat Pliva
    Pliva, Bosnia & Herzegowina; Pliva, Croatia (Hrvatska)
  • Kalcijev folinat Sandoz
    Sandoz, Croatia (Hrvatska)
  • Kalcium Folinat Pliva
    Pliva Hrvatska, Macedonia
  • Kalciumfolinat Stada
    STADA Nordic, Sweden
  • Kalsiumfolinat Pfizer
    Pfizer, Norway
  • Kalsiyum Folinat Ebewe
    Ebewe, Turkey
  • Kang Da Li Ping
    Tian Fu Pharmaceutical Factory, China
  • Kang Lai Er
    XiaDu Pharmaceutical, China
  • Komfer-Fol [+ Ferric Proteinsuccinylate]
    Koçak, Turkey
  • Lederfolin
    Pfizer, Spain
  • Lederfoline
    Pfizer, France; Teofarma, Portugal
  • Lederle Leucovorin
    Pfizer, Canada
  • Leucocalcin
    Kampel Martian, Paraguay
  • Leucocalcin 15
    LKM, Argentina
  • Leucocin
    Pharmedic, Pakistan
  • Leuconolver
    Nolver, Venezuela
  • Leucovorin
    Atco, Pakistan; Pfizer Japan, Japan; Pfizer Pharmaceuticals Ltd, China; Teva, Israel; Umair, Pakistan
  • Leucovorin 10mg/ml
    Pharmachemie, Israel
  • Leucovorin 15 Libra
    Libra, Paraguay
  • Leucovorin 50 Libra
    Libra, Paraguay
  • Leucovorin Ca Lachema 25
    Lachema, Lithuania
  • Leucovorin Calcium
    Barr, United States; Hospira UK Ltd., Oman; MediNet, Lithuania; Pfizer, Bosnia & Herzegowina; Teva, United States
  • Leucovorin Calcium 50mg Lederle
    Lederle, Kuwait
  • Leucovorin Calcium 50mg/5ml
    Cyanamid, Oman
  • Leucovorin Calcium 50mg/5ml Faulding
    Faulding, Kuwait
  • Leucovorin Calcium DBL
    Tempo Scan Pacific/Hospira, Indonesia
  • Leucovorin Calcium Farmos 15mg
    Orion Pharma, Switzerland
  • Leucovorin Calcium Farmos 30mg/10ml
    Orion Pharma, Switzerland
  • Leucovorin Calcium Fresenius Kabi
    Fresenius Kabi, Thailand
  • Leucovorin Calcium Pfizer
    Pfizer, Australia; Pfizer, Canada; Pfizer, Taiwan
  • Leucovorin Calcium Pharmachemie
    Pharmachemie, Taiwan
  • Leucovorin Calcium Teva
    Teva Canada, Canada
  • Leucovorin Kalbe
    Kalbe, Indonesia
  • Leucovorin Kalcijum
    Pfizer H.C.P., Serbia
  • Leucovorin Pharmacenter 10 mg/ml
    Pharmacenter, Hungary
  • Leucovorina
    Oncomed, Peru
  • Leucovorina 15 Farmaco Urug.
    Farmaco Urug., Paraguay
  • Leucovorina 15mg DF
    Sidus, Paraguay
  • Leucovorina 25 Farmaco Urug.
    Farmaco Urug., Paraguay
  • Leucovorina 50 FU
    Farmaco Urug., Paraguay
  • Leucovorina 50mg DF
    Sidus, Paraguay
  • Leucovorina Calcica
    Pfizer, Ecuador; Pfizer, Venezuela
  • Leucovorina Calcica FA.PA.SA.
    FA.PA.SA., Paraguay
  • Leucovorina Calcico Fusa 100
    Farmaco Urug., Paraguay
  • Leucovorina Filaxis
    GP Pharm, Argentina
  • Leucovorina Richet
    Richet, Paraguay
  • Leucovorina Teva
    Teva-Tuteur, Paraguay
  • Leucovorin-Calcium
    Farmar, Turkey
  • Leucovorin-Teva
    Teva, Lithuania; Teva, Latvia; Teva Ilac, Turkey; Teva Pharmaceutical Works, Georgia
  • Leucovorin-Teva 10 mg/ml
    Teva, Hungary
  • Leucovorin-Teva 100mg/10ml
    Teva Pharma, Switzerland
  • Leucovorin-Teva 300mg/30ml
    Teva Pharma, Switzerland
  • Leucovorin-Teva 500mg/50ml
    Teva Pharma, Switzerland
  • Leucovorin-Teva 50mg/5ml
    Teva Pharma, Switzerland
  • Li Lei Te
    Dadeli Biochemical Pharmaceutical Factory, China
  • Likelin
    Hospira, China
  • Litacor
    Korea United Pharma, Philippines
  • Lovorin
    Biomedis Oncology, Philippines
  • Lu Wei Fen
    Heng Da Pharm, China
  • Lucal
    Celon, India
  • Medifolin
    Medinfar, Malta; Medinfar, Portugal
  • Novizet
    Microsules, Paraguay
  • Nyrin
    Eimc, Egypt
  • Ou Li
    Wanma Pharmaceutical, China
  • Quefuli
    Sandoz China, China
  • Recovorin
    Cadila HC, India
  • Refolinon
    Pfizer, United Kingdom
  • Reotan
    Medicus, Greece
  • Rescuvolin
    Chemipharm, Greece; Combiphar/Pharmachemie, Indonesia; Medac, China; Pharmachemie, Bangladesh; Pharmachemie, Malaysia; Pharmachemie, Taiwan; Pharmachemie/Teva, Thailand; Teva, Georgia; Teva Pharma Belgium, Belgium
  • Rescuvolin 100mg
    medac, Germany
  • Rescuvolin 15mg
    Teva, Luxembourg
  • Rescuvolin 200mg
    medac, Germany
  • Rescuvolin 300mg
    medac, Germany
  • Rescuvolin 500mg
    medac, Germany
  • Rescuvolin 900mg
    medac, Germany
  • Ribofolin 10mg/ml
    Ribosepharm division Hikma Pharma, Germany
  • Rontafor
    Gobbi-Novag, Argentina
  • Sanficinate
    Sanofi-Aventis, Lithuania
  • Sanifolin
    JV Healthcare Limited, Malta
  • Shiming
    Yaoyou Pharmaceutical, China
  • Si Min Le
    Nuojin Pharmaceutical, China
  • Stressen [+ Arginine, + Cobamamide]
    Medosan, Italy
  • Tecnovorin
    Zodiac, Brazil
  • Tong Ao
    HengRui Medicine, China
  • Tonofolin
    Teofarma, Italy
  • Uzel
    Taiho Yakuhin, Japan
  • Veravorin
    Opus Materia, Greece
  • Vivalcid
    Folium I.K.E., Greece
  • Ya Fu Xin
    Tiancheng Pharmaceutical, China
  • Abic Leucovorin
    Teva Pharmaceuticals, South Africa
  • Calcio Folinato Sandoz
    Sandoz, Italy
  • Calcium Folinate Stada
    Cell Pharm, Bulgaria
  • Calcium Folinate Teva
    Teva, Czech Republic
  • Calciumfolinat Ebewe
    Ebewe, Estonia; Sandoz, Denmark; Sandoz, Sweden; Ebewe Pharma, Czech Republic
  • Calciumfolinat HEXAL
    Hexal, Germany
  • Calciumfolinat-GRY
    Teva, Germany
  • Ecofol
    Ecobi, Italy
  • Ferplex-Fol [+ Ferrous Succinate]
    Abdi Ibrahim, Turkey
  • Foliment
    Bennett SA, Greece
  • Folinezuur Sandoz
    Sandoz, Netherlands
  • Fysiofol [+ Ferric Proteinsuccinylat]
    ITF, Greece
  • Lederfolat
    Teofarma, Germany
  • Legofolin [+ Ferrous Succinate]
    ITF, Greece
  • Leucovorin
    Pfizer, Germany; Pfizer, Greece
  • Leucovorin Ca Teva
    Teva Pharmaceuticals, Poland
  • Leucovorin Calcium
    West-Ward, United States
  • Leucovorine Sandoz
    Sandoz, Netherlands
  • Lizocalcio
    S.J.A., Greece
  • Osfolato
    Mayoly Spindler, Italy
  • Rescuvolin
    Pharmachemie, Netherlands
  • Sanifolin
    Fargim, Italy
  • Sulton
    Geymonat, Italy
  • Zenemia
    Verisfield, Greece

Glossary

TermDefinition
BANMBritish Approved Name (Modified)
DCITDenominazione Comune Italiana
ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
WHOWorld Health Organization

Further information on drug naming conventions: International Nonproprietary Names.

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Further information

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