Calcium Folinate (International)

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

V03AF03

CAS registry number (Chemical Abstracts Service)

0001492-18-8

Chemical Formula

C20-H21-Ca-N7-O7

Molecular Weight

512

Therapeutic Categories

Antidote against folic acid antagonists

Detoxifying agent for antineoplastic treatment

Chemical Name

Calcium N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)metyl]amino]benzoyl]glutamate (WHO)

Foreign Names

• Calcii folinas (Latin)
• Calcium folinat (German)
• Folinate de calcium (French)
• Folinato cálcico (Spanish)

Generic Names

• Calcium Folinate (OS: JAN, BANM)
• Folinato di calcio (OS: DCIT)
• (+)-L-Folinic acid, calcium salt (IS)
• Calcifolin (IS)
• Calcio folinato (IS)
• Calcium citrovorum factor (IS)
• Calfonat (IS)
• Folinat-SF Calcium (IS)
• Folinic acid calcium salt (IS)
• Leucovorin Calcium (IS)
• Calcii folinas (PH: Ph. Eur. 9, Ph. Int. 7)
• Calcium Folinate (PH: BP 2018, JP XVII, Ph. Int. 7)
• Calcium folinate (PH: Ph. Eur. 9)
• Leucovorin Calcium (PH: USP 41)
• Folinsäure, Calciumsalz-5-Wasser (IS)
• NSC 3590 (IS)

Brand Names

• Ai Jie Kang
  Hua Lu Pharm, China
• Ai Ru Xi
  Tian Yu Pharmaceutical, China
• Antrex
  Orion, China; Orion, Taiwan; Orion Pharma, Finland
• Bendafolin [+ Folinic acid]
  Bendalis, Bulgaria
• Bendafolin 10mg/ml
  Bendalis, Germany
• Bicomplex [+ Riboflavin, + Nicotinamide, + Cyanocobalamin, + Thiamine]
  ABC Farmaceutici, Georgia
• Bloodlet
  Yung Shin, Taiwan
• Buateron
  Venifar Ltd, Greece
• Cafona
  Synmosa, Taiwan
• Cafonate
  Naprod, Philippines; Naprod Life Sciences, Thailand
• Cafonia
  Yuan Chou, Taiwan
• Calcifolin
  Ibirn, Italy; Provident Azrneimittel AG, Greece
• Calcilinat F100
  Binhdinh Pharmaceutical and Medical Equipment Company Bidiphar, Vietnam
• Calcilinat F50
  Binhdinh Pharmaceutical and Medical Equipment Company Bidiphar, Vietnam
• Calcio Folinato ESP Pharma
  ESP Pharma, Italy
• Calcio Folinato Pliva
  BioHealth Pharmaceuticals, Italy
• Calcium Folinat
  Ebewe, Lebanon
• Calcium Folinat Ebewe
  Ebewe, Romania; Sandoz, Australia
• Calcium Folinate
  Bio Pharma, Pakistan; Consilient Health, United Kingdom; Ebewe, Lebanon; Generics UK, United Kingdom; Hospira UK, United Kingdom; Pfizer, Thailand; Rue Belmedpreparaty, Georgia
• Calcium Folinate - Cuccess Pharm
  Nanjing Cuccess Pharmaceutical, China
• Calcium Folinate - Wanma Pharm
  Wanma Pharmaceutical, China
• Calcium folinate Acdima
  Acdima, Egypt
• Calcium folinate Actavis
  Actavis, Macedonia
• Calcium folinate Al Masria
  Al Masria, Egypt
• Calcium folinate Baxter
  Baxter, New Zealand
• Calcium folinate Dbl
  Dbl, Egypt
• Calcium Folinate Ebewe
  Ferron/Ebewe, Indonesia; Novartis, New Zealand
• Calcium folinate Ebewe
  Ebewe, Egypt
• Calcium Folinate Hospira
  Hospira, Malta
• Calcium folinate Hospira
  Hospira, Egypt
• Calcium Folinate Kabi
  Fresenius Kabi, Poland; Fresenius Kabi Deutschland, Malta
• Calcium Folinate Kocak
  Kocak Farma, Turkey
• Calcium folinate Merck
  Merck, Egypt
• Calcium Folinate Sandoz
  Ebewe Pharma, Bulgaria; Novartis, New Zealand; Sandoz, Czech Republic; Sandoz, Lithuania; Sandoz, Poland; Sandoz, Sweden; Sandoz, Slovakia
• Calcium Folinate Trading
  Pharmaceutical Trading, Cyprus
• Calcium Folinate-DBL
  Orna, Turkey
• Calcium Leucovorin
  Wyeth, India
• Calcium Leucovorin Lederle
  Lederle, Kuwait
• Calciumfolinat
  Ebewe, Latvia
• Calciumfolinat Amneal
  Amneal Deutschland, Germany
• Calciumfolinat aries
  Apocare, Germany
• Calciumfolinat axios
  Axios, Germany
• Calciumfolinat Bhardwaj
  Tillomed Pharma, Germany
• CALCIUMFOLINAT biosyn
  Biosyn, Germany
• Calciumfolinat Ebewe
  Ebewe, Serbia; Ebewe, Slovakia; Ebewe, Tunisia; Ebewe Pharma, Bulgaria; Ebewe Pharma, Macedonia; Würth, Croatia (Hrvatska)
• Calciumfolinat Ebewe 10 mg/ml
  Ebewe Pharma, Austria
• Calciumfolinat Ebewe 15 mg
  Ebewe, Hungary; Ebewe Pharma, Austria
• Calciumfolinat Ebewe 1omg/ml
  Ebewe, Israel
• Calciumfolinat Fresenius Kabi
  Fresenius Kabi, Denmark
• Calciumfolinat Heumann
  Heumann, Germany
• Calciumfolinat Hospira
  Hospira, Germany; Hospira, Sweden; Hospira Nordic, Denmark
• Calciumfolinat Kabi
  Fresenius Kabi Deutschland, Germany
• Calciumfolinat Kabi 10 mg/ml
  Fresenius Kabi, Austria
• Calciumfolinat Medipolis
  Medipolis Produktion, Germany
• Calciumfolinat onkovis
  Onkovis, Germany
• Calciumfolinat Profusio
  PGD Profusio Haan, Germany
• Calciumfolinat Sandoz 10 mg/ml
  Sandoz, Austria
• Calciumfolinat Sandoz 15mg
  Sandoz, Switzerland
• Calciumfolinat Sandoz eco 100mg/10ml
  Sandoz, Switzerland
• Calciumfolinat Sandoz eco 500mg/50ml
  Sandoz, Switzerland
• Calciumfolinat Sandoz eco 50mg/5ml
  Sandoz, Switzerland
• Calciumfolinat Stada 10 mg/ml
  Stada Arzneimittel, Austria
• Calciumfolinat SUN
  SUN Pharmaceuticals Germany, Germany
• Calciumfolinat Vipharm
  Vipharm, Germany
• Calciumfolinate
  Teva, Norway
• Calciumfolinate Sandoz
  Sandoz, Denmark
• Calciumfolinate Teva
  Teva, Sweden
• Calciumfolinat-Ebewe
  Ebewe, Poland; Ebewe, Taiwan; Sandoz, Hong Kong; Sandoz, Thailand
• Calfolex
  Sirton Medicare, Italy
• Calfolin
  Johnson, Taiwan
• Citofolin
  Bracco, Italy
• Covorin
  Patron, Taiwan
• Cromatonbic Ferro [+ Cyanocobalamin]
  Menarini, Costa Rica; Menarini, Dominican Republic; Menarini, Guatemala; Menarini, Honduras; Menarini, Nicaragua; Menarini, Panama; Menarini, El Salvador
• DBL Calcium Folinate
  Hospira Singapore, Singapore
• DBL Leucovorin Calcium
  Pfizer, Australia; Pfizer, New Zealand
• Eparmefolin [+ Cyanocobalamin]
  Bracco, Italy
• Estroquin 15
  Richmond, Paraguay; Richmond, Uruguay
• Estroquin 50
  Richmond, Paraguay; Richmond, Uruguay
• Etamolin
  AC Farma, Peru
• Fauldleuco
  Libbs, Brazil
• Fedolen
  Viofar, Greece
• Ferbon
  Samjin, South Korea
• Ferrofolin [+ Ferric Proteinsuccinylate]
  SIT, Italy
• Folaren
  Ist.Chim.Intern.Rende, Italy
• Folcasin
  Actavis, Romania; Actavis D.O.O., Serbia
• Folidar
  Italfarmaco, Italy
• Folikabi
  Fresenius Kabi Deutschland GmbH, Netherlands
• Folina
  TTY Biopharm, Taiwan
• Folinat de Calciu Kabi
  Fresenius Kabi Deutschland, Romania
• Folinat de Calciu Teva
  Teva Romania, Romania
• Folinate de calcium Aguettant
  Aguettant, France; Aguettant, Tunisia
• Folinate de calcium Sandoz
  Sandoz, France
• Folinate de calcium Zentiva
  Sanofi-Aventis, France
• Folinate EG
  Eurogenerics, Belgium
• Folinate EG 200mg/20ml
  Eurogenerics, Luxembourg
• Folinate EG 500mg/50ml
  Eurogenerics, Luxembourg
• Folinato
  Angelini Pharma, Greece
• Folinato Cálcico
  Perulab, Peru
• Folinato Calcico G.E.S.
  Ges Genericos, Spain
• Folinato Calcico Genfarma
  Genfarma, Spain
• Folinato Calcico Normon
  Normon, Spain
• Folinato Calcico Sandoz
  Sandoz España, Spain
• Folinato Calcico Teva
  Teva, Spain
• Folinato Calcio (Leucovorina Calcia) Pharma Arte
  Pharma Arte, Paraguay
• Folinato de Calcio
  Vitalis, Peru
• Folinato de cálcio Hikma
  Hikma Farmacêutica Portugal, Portugal
• Folinato de cálcio Kabi
  Fresenius Kabi, Portugal
• Folinato de Cálcio Teva
  Teva Pharma, Portugal
• Folinato de Calcio Vitalis
  Vitalis, Costa Rica
• Folinfabra
  Fabra, Argentina
• Folinic Acid
  FIT-BioCeuticals, Australia; Hospira, Ireland
• Folinic Mouthwash
  Extemporaneous Product, New Zealand
• Folinico Acido
  Precimex, Mexico
• Folinoral
  Thérabel Lucien, France
• Fu Neng
  Ling Nan Pharmaceutical, China
• Gai Er Qing
  Ya Bao Pharma Group, China
• HAEMATO-folin
  HAEMATO PHARM, Germany
• Hospira Leucovorin Calcium
  Hospira, Philippines
• Innefol
  Pisa, Mexico
• Kalcijev folinat Pliva
  Pliva, Bosnia & Herzegowina; Pliva, Croatia (Hrvatska)
• Kalcijev folinat Sandoz
  Sandoz, Croatia (Hrvatska)
• Kalcium Folinat Pliva
  Pliva Hrvatska, Macedonia
• Kalciumfolinat Stada
  STADA Nordic, Sweden
• Kalsiumfolinat Pfizer
  Pfizer, Norway
• Kalsiyum Folinat Ebewe
  Ebewe, Turkey
• Kang Da Li Ping
  Tian Fu Pharmaceutical Factory, China
• Kang Lai Er
  XiaDu Pharmaceutical, China
• Komfer-Fol [+ Ferric Proteinsuccinylate]
  Koçak, Turkey
• Lederfolin
  Pfizer, Spain
• Lederfoline
  Pfizer, France; Teofarma, Portugal
• Lederle Leucovorin
  Pfizer, Canada
• Leucocalcin
  Kampel Martian, Paraguay
• Leucocalcin 15
  LKM, Argentina
• Leucocin
  Pharmedic, Pakistan
• Leuconolver
  Nolver, Venezuela
• Leucovorin
  Atco, Pakistan; Pfizer Japan, Japan; Pfizer Pharmaceuticals Ltd, China; Teva, Israel; Umair, Pakistan
• Leucovorin 10mg/ml
  Pharmachemie, Israel
• Leucovorin 15 Libra
  Libra, Paraguay
• Leucovorin 50 Libra
  Libra, Paraguay
• Leucovorin Ca Lachema 25
  Lachema, Lithuania
• Leucovorin Calcium
  Barr, United States; Hospira UK Ltd., Oman; MediNet, Lithuania; Pfizer, Bosnia & Herzegowina; Teva, United States
• Leucovorin Calcium 50mg Lederle
  Lederle, Kuwait
• Leucovorin Calcium 50mg/5ml
  Cyanamid, Oman
• Leucovorin Calcium 50mg/5ml Faulding
  Faulding, Kuwait
• Leucovorin Calcium DBL
  Tempo Scan Pacific/Hospira, Indonesia
• Leucovorin Calcium Farmos 15mg
  Orion Pharma, Switzerland
• Leucovorin Calcium Farmos 30mg/10ml
  Orion Pharma, Switzerland
• Leucovorin Calcium Fresenius Kabi
  Fresenius Kabi, Thailand
• Leucovorin Calcium Pfizer
  Pfizer, Australia; Pfizer, Canada; Pfizer, Taiwan
• Leucovorin Calcium Pharmachemie
  Pharmachemie, Taiwan
• Leucovorin Calcium Teva
  Teva Canada, Canada
• Leucovorin Kalbe
  Kalbe, Indonesia
• Leucovorin Kalcijum
  Pfizer H.C.P., Serbia
• Leucovorin Pharmacenter 10 mg/ml
  Pharmacenter, Hungary
• Leucovorina
  Oncomed, Peru
• Leucovorina 15 Farmaco Urug.
  Farmaco Urug., Paraguay
• Leucovorina 15mg DF
  Sidus, Paraguay
• Leucovorina 25 Farmaco Urug.
  Farmaco Urug., Paraguay
• Leucovorina 50 FU
  Farmaco Urug., Paraguay
• Leucovorina 50mg DF
  Sidus, Paraguay
• Leucovorina Calcica
  Pfizer, Ecuador; Pfizer, Venezuela
• Leucovorina Calcica FA.PA.SA.
  FA.PA.SA., Paraguay
• Leucovorina Calcico Fusa 100
  Farmaco Urug., Paraguay
• Leucovorina Filaxis
  GP Pharm, Argentina
• Leucovorina Richet
  Richet, Paraguay
• Leucovorina Teva
  Teva-Tuteur, Paraguay
• Leucovorin-Calcium
  Farmar, Turkey
• Leucovorin-Teva
  Teva, Lithuania; Teva, Latvia; Teva Ilac, Turkey; Teva Pharmaceutical Works, Georgia
• Leucovorin-Teva 10 mg/ml
  Teva, Hungary
• Leucovorin-Teva 100mg/10ml
  Teva Pharma, Switzerland
• Leucovorin-Teva 300mg/30ml
  Teva Pharma, Switzerland
• Leucovorin-Teva 500mg/50ml
  Teva Pharma, Switzerland
• Leucovorin-Teva 50mg/5ml
  Teva Pharma, Switzerland
• Li Lei Te
  Dadeli Biochemical Pharmaceutical Factory, China
• Likelin
  Hospira, China
• Litacor
  Korea United Pharma, Philippines
• Lovorin
  Biomedis Oncology, Philippines
• Lu Wei Fen
  Heng Da Pharm, China
• Lucal
  Celon, India
• Medifolin
  Medinfar, Malta; Medinfar, Portugal
• Novizet
  Microsules, Paraguay
• Nyrin
  Eimc, Egypt
• Ou Li
  Wanma Pharmaceutical, China
• Quefuli
  Sandoz China, China
• Recovorin
  Cadila HC, India
• Refolinon
  Pfizer, United Kingdom
• Reotan
  Medicus, Greece
• Rescuvolin
  Chemipharm, Greece; Combiphar/Pharmachemie, Indonesia; Medac, China; Pharmachemie, Bangladesh; Pharmachemie, Malaysia; Pharmachemie, Taiwan; Pharmachemie/Teva, Thailand; Teva, Georgia; Teva Pharma Belgium, Belgium
• Rescuvolin 100mg
  medac, Germany
• Rescuvolin 15mg
  Teva, Luxembourg
• Rescuvolin 200mg
  medac, Germany
• Rescuvolin 300mg
  medac, Germany
• Rescuvolin 500mg
  medac, Germany
• Rescuvolin 900mg
  medac, Germany
• Ribofolin 10mg/ml
  Ribosepharm division Hikma Pharma, Germany
• Rontafor
  Gobbi-Novag, Argentina
• Sanficinate
  Sanofi-Aventis, Lithuania
• Sanifolin
  JV Healthcare Limited, Malta
• Shiming
  Yaoyou Pharmaceutical, China
• Si Min Le
  Nuojin Pharmaceutical, China
• Stressen [+ Arginine, + Cobamamide]
  Medosan, Italy
• Tecnovorin
  Zodiac, Brazil
• Tong Ao
  HengRui Medicine, China
• Tonofolin
  Teofarma, Italy
• Uzel
  Taiho Yakuhin, Japan
• Veravorin
  Opus Materia, Greece
• Vivalcid
  Folium I.K.E., Greece
• Ya Fu Xin
  Tiancheng Pharmaceutical, China
• Abic Leucovorin
  Teva Pharmaceuticals, South Africa
• Calcio Folinato Sandoz
  Sandoz, Italy
• Calcium Folinate Stada
  Cell Pharm, Bulgaria
• Calcium Folinate Teva
  Teva, Czech Republic
• Calciumfolinat Ebewe
  Ebewe, Estonia; Sandoz, Denmark; Sandoz, Sweden; Ebewe Pharma, Czech Republic
• Calciumfolinat HEXAL
  Hexal, Germany
• Calciumfolinat-GRY
  Teva, Germany
• Ecofol
  Ecobi, Italy
• Ferplex-Fol [+ Ferrous Succinate]
  Abdi Ibrahim, Turkey
• Foliment
  Bennett SA, Greece
• Folinezuur Sandoz
  Sandoz, Netherlands
• Fysiofol [+ Ferric Proteinsuccinylat]
  ITF, Greece
• Lederfolat
  Teofarma, Germany
• Legofolin [+ Ferrous Succinate]
  ITF, Greece
• Leucovorin
  Pfizer, Germany; Pfizer, Greece
• Leucovorin Ca Teva
  Teva Pharmaceuticals, Poland
• Leucovorin Calcium
  West-Ward, United States
• Leucovorine Sandoz
  Sandoz, Netherlands
• Lizocalcio
  S.J.A., Greece
• Osfolato
  Mayoly Spindler, Italy
• Rescuvolin
  Pharmachemie, Netherlands
• Sanifolin
  Fargim, Italy
• Sulton
  Geymonat, Italy
• Zenemia
  Verisfield, Greece

Glossary

Further information on drug naming conventions: International Nonproprietary Names.

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