Skip to main content


Note: In some countries, this medicine may only be approved for veterinary use.



ATC (Anatomical Therapeutic Chemical Classification)


CAS registry number (Chemical Abstracts Service)


Chemical Formula


Molecular Weight


Therapeutic Categories

Dietary supplement

Antirheumatic agent

Chemical Name

(±)-5'-[(R*)-[(R*)-3-amino-3-carboxypropyl]metylsulfonio]-5'-deoxy-adenosine hydroxide, inner salt (WHO)

Foreign Names

  • Ademetioninum (Latin)
  • Ademetionin (German)
  • Adémétionine (French)
  • Ademetionina (Spanish)

Generic Names

  • Adenosylmethionin (IS)
  • Methioninyl Adenylate (IS)
  • S-Adenosyl-L-Methionine (IS)
  • S-Adenosyl-Methionine (IS)
  • S-Adénosyl-Méthionine (IS)
  • SAM (IS)
  • SAMe (IS)
  • SAM-e (IS)
  • Ademetionine 1,4-butanedisulfonate (IS)
  • S-Adenosylmethionine 1,4-Butanedisulfonate (IS)
  • UNII-C5BTS0548U (IS)
  • Ademetionine Sulfate Tosilate (OS: JAN)
  • Ademetionine disulfate di-p-toluenesulfonate (IS)
  • Ademetionine Disulfate Tosylate (IS)

Brand Names

  • Adenomac
    Macleods, India
  • Adenorich
    Future, India
  • Adesam
    Sun, India
  • Aronin
    Korea Prime Pharm, South Korea
  • Denosyl [veterinary use]
    Vetpharm, New Zealand
  • Donamet
    Abbott, Italy
  • Gepsam
    Lisapharma, Georgia; Vigifarma, Lithuania
  • Heptral
    Abbott, Malaysia; Abbott Laboratories S, Singapore
  • Ostisave
    Zydus, India
  • Sammy
    Wockhardt, India
  • Transmetil
    Abbott, Italy; Abbott Laboratories S.A., China; BGP Products, Czech Republic
  • Ademetionine
    Vial, Russian Federation
  • Ademta
    Mefar Ilaç Sanayii, Georgia
  • Cereliv-Humanity
    BDR Pharmaceuticals, Georgia
  • Heptolan
    EuroMedical, Georgia
  • Heptral
    AbbVie, Georgia; AbbVie, Russian Federation; Famar, Russian Federation; Famar L'Aigle, Georgia; Hospira, Russian Federation
  • Legend
    Biomedica Foscama, Georgia
  • Samyr
    Abbott, Italy
  • Transmetil
    Famar L'Aigle, Bulgaria; Hospira, Bulgaria
  • Tunik 100
    Brandt, Uruguay
  • Tunik 100 B12 [+ Cyanocobalamin]
    Brandt, Uruguay
  • Samyr
    Abbott Laboratories de México, Mexico


ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
WHOWorld Health Organization

Further information on drug naming conventions: International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.