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In some countries, this medicine may only be approved for veterinary use.



ATC (Anatomical Therapeutic Chemical Classification)


CAS registry number (Chemical Abstracts Service)


Chemical Formula


Molecular Weight


Therapeutic Categories

Dietary supplement

Antirheumatic agent

Chemical Name

(±)-5'-[(R*)-[(R*)-3-amino-3-carboxypropyl]metylsulfonio]-5'-deoxy-adenosine hydroxide, inner salt (WHO)

Foreign Names

  • Ademetioninum (Latin)
  • Ademetionin (German)
  • Adémétionine (French)
  • Ademetionina (Spanish)

Generic Names

  • Adenosylmethionin (IS)
  • Methioninyl Adenylate (IS)
  • S-Adenosyl-L-Methionine (IS)
  • S-Adenosyl-Methionine (IS)
  • S-Adénosyl-Méthionine (IS)
  • SAM (IS)
  • SAMe (IS)
  • SAM-e (IS)
  • Ademetionine disulfate di-p-toluenesulfonate (IS)
  • Ademetionine Disulfate Tosylate (IS)
  • S-Adenosyl-L-methionine Disulfate Tosylate (PH: USP 37)

Brand Names

  • Denosyl (veterinary use)
    Ceva Animal Health, Australia; Vetpharm, New Zealand
  • Donamet
    Abbott, Italy
  • Heptor
    Verofarm, Russian Federation
  • Heptral
    Abbott, Georgia; Abbott, Malaysia; Abbott, Singapore
  • Ostisave
    Zydus, India
  • Sammy
    Wockhardt, India
  • Samyr
    Abbott, Colombia; Abbott, Italy
  • Transmetil
    Abbott, China; Abbott, Italy; Abbott, Vietnam; Boehringer Ingelheim, Colombia; Hospira, Bulgaria
  • Tunik
    Baliarda, Argentina
  • Heptral
    Abbott, Russian Federation
  • Novifit (veterinary use)
    Virbac, France
  • Samyr
    Abbott, Mexico
  • Transmetil
    Abbott, Czech Republic

International Drug Name Search


ISInofficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
WHOWorld Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.