Drug Interaction Report
6 potential interactions and/or warnings found for the following 2 drugs:
- desmopressin
- Promethazine VC with Codeine (codeine / phenylephrine / promethazine)
Interactions between your drugs
codeine desmopressin
Applies to: Promethazine VC with Codeine (codeine / phenylephrine / promethazine), desmopressin
Codeine can sometimes enhance the effects of desmopressin. Although not common, this may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In serious cases, hyponatremia can lead to seizure, coma, or even death. You should seek immediate medical attention if you experience loss of appetite, nausea, vomiting, drowsiness, fatigue, weakness, headache, confusion, difficulty concentrating, memory impairment, decreased urination, and/or sudden weight gain, as these may be early signs and symptoms of water intoxication and hyponatremia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
codeine promethazine
Applies to: Promethazine VC with Codeine (codeine / phenylephrine / promethazine), Promethazine VC with Codeine (codeine / phenylephrine / promethazine)
Using codeine together with promethazine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
codeine food
Applies to: Promethazine VC with Codeine (codeine / phenylephrine / promethazine)
Do not use alcohol or medications that contain alcohol while you are receiving treatment with codeine. This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. With certain long-acting formulations of narcotic pain medication, consumption of alcohol may also cause rapid release of the drug, resulting in high blood levels that may be potentially lethal. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Do not use more than the recommended dose of codeine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.
promethazine food
Applies to: Promethazine VC with Codeine (codeine / phenylephrine / promethazine)
Ask your doctor before using promethazine together with ethanol. This can cause uncontrollable movements, agitation, seizures, severe dizziness or fainting, coma, very deep sleep, irregular heartbeats, and high or low body temperature. Use caution when driving, operating machinery, or performing other hazardous activities, these medicaions may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
phenylephrine food
Applies to: Promethazine VC with Codeine (codeine / phenylephrine / promethazine)
Both phenylephrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
desmopressin food
Applies to: desmopressin
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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