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Drug Interaction Report

2 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

benzoyl peroxide topical adapalene topical

Applies to: Epiduo (adapalene / benzoyl peroxide topical), Epiduo (adapalene / benzoyl peroxide topical)

GENERALLY AVOID: Concomitant use of retinoids and keratolytic or astringent topicals may result in excessive irritation and/or drying.

MANAGEMENT: Depending on circumstances (e.g., areas of application), concomitant use should preferably be avoided, and a rest period considered in between use of these products.

References (2)
  1. (2001) "Product Information. Retin-A (tretinoin)." Ortho McNeil Pharmaceutical
  2. (2001) "Product Information. Tazorac (tazarotene topical)." Allergan Inc
Minor

benzoyl peroxide topical dapsone topical

Applies to: Epiduo (adapalene / benzoyl peroxide topical), dapsone topical

In one clinical study, topical application of dapsone followed by benzoyl peroxide in subjects with acne vulgaris was associated with a temporary local yellow or orange discoloration of the skin and facial hair in 7 out of 95 subjects, with resolution in 4 to 57 days. The mechanism of interaction is unknown.

References (1)
  1. (2005) "Product Information. Aczone (dapsone topical)." QLT USA, Inc

Drug and food interactions

No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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