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Drug Interaction Report

1 potential interaction and/or warning found for the following 2 drugs:

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Interactions between your drugs

Moderate

clindamycin attapulgite

Applies to: Cleocin Phosphate (clindamycin), Diarrest (attapulgite)

GENERALLY AVOID: Adsorbent antidiarrheal agents may significantly reduce the gastrointestinal absorption of oral clindamycin and lincomycin, causing decreased serum levels and potential loss of antimicrobial effectiveness. Kaolin-pectin has been associated with a 90% reduction in lincomycin levels.

MANAGEMENT: The use of adsorbent antidiarrheals should be avoided if possible. If used concurrently, the patient should be monitored closely for loss of antibiotic efficacy.

References

  1. Albert KS, DeSante KA, Welch RD, DiSanto AR (1978) "Pharmacokinetic evaluation of a drug interaction between kaolin-pectin and clindamycin." J Pharm Sci, 67, p. 1579-82
  2. (2002) "Product Information. Cleocin (clindamycin)." Pharmacia and Upjohn
  3. (2001) "Product Information. Lincocin (lincomycin)." Pharmacia and Upjohn
  4. McCall CE, Steigbigel NH, Finland M (1967) "Lincomycin: activity in vitro and absorption and excretion in normal young men." Am J Med Sci, 254, p. 144-55
  5. McGehee RF Jr, Smith CB, Wilcox C, Finland M (1968) "Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clindamycin." Am J Med Sci, 256, p. 279-92
View all 5 references

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Drug and food interactions

No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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