Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- givinostat
- romidepsin
Interactions between your drugs
romiDEPsin givinostat
Applies to: romidepsin, givinostat
Using givinostat together with romiDEPsin may increase the risk of experiencing a change in the electrical activity of your heart called QT prolongation, which may result in irregular heartbeats that can be life-threatening. You might be more susceptible to this risk if you have heart problems or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting, which are commonly reported as side effects of givinostat treatment). Your doctor may be able to prescribe alternatives that do not interact, or you may need more frequent monitoring of your electrocardiogram to safely use both medications. You should seek immediate medical attention if you experience an irregular heartbeat or feel dizzy, lightheaded, or faint during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
givinostat food
Applies to: givinostat
Food increases the absorption of givinostat. To ensure adequate blood levels of the medication, givinostat should be administered with food. Additionally, food can help mask the bitter taste of the oral suspension. Follow up with your healthcare professional if you have any additional questions.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Histone deacetylase inhibitors
Therapeutic duplication
The recommended maximum number of medicines in the 'histone deacetylase inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'histone deacetylase inhibitors' category:
- givinostat
- romidepsin
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Duvyzat
Duvyzat (givinostat) is used to treat Duchenne muscular dystrophy (DMD) to delay symptoms and ...
Agamree
Agamree (vamorolone) is an FDA-approved treatment for Duchenne muscular dystrophy (DMD) to improve ...
Emflaza
Emflaza (deflazacort) is a corticosteroid medication used to treat a rare genetic disorder called ...
Viltepso
Viltepso (viltolarsen) is used for the treatment of Duchenne muscular dystrophy (DMD) treatable ...
Elevidys
Elevidys is a gene therapy for Duchenne muscular dystrophy, that is given as a one-time infusion ...
Amondys 45
Amondys 45 (casimersen) is used to treat Duchenne muscular dystrophy (DMD) with a genetic mutation ...
Vyondys 53
Vyondys 53 is used for Duchenne muscular dystrophy (DMD) in children and young adults with a ...
Exondys 51
Exondys 51 is used for Duchenne Muscular Dystrophy (DMD) in children and young adults with a ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.