Drug Interaction Report

Using givinostat together with romiDEPsin may increase the risk of experiencing a change in the electrical activity of your heart called QT prolongation, which may result in irregular heartbeats that can be life-threatening. You might be more susceptible to this risk if you have heart problems or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting, which are commonly reported as side effects of givinostat treatment). Your doctor may be able to prescribe alternatives that do not interact, or you may need more frequent monitoring of your electrocardiogram to safely use both medications. You should seek immediate medical attention if you experience an irregular heartbeat or feel dizzy, lightheaded, or faint during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food increases the absorption of givinostat. To ensure adequate blood levels of the medication, givinostat should be administered with food. Additionally, food can help mask the bitter taste of the oral suspension. Follow up with your healthcare professional if you have any additional questions.

The recommended maximum number of medicines in the 'histone deacetylase inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'histone deacetylase inhibitors' category:

• givinostat
• romidepsin

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.