Drug Interaction Report

Esketamine can cause transient but significant increases in blood pressure, and using it with methylene blue may increase the risk. Let your doctor know if you have been using methylene blue prior to getting treatment with esketamine. You may need a dose adjustment or more frequent monitoring of your blood pressure to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Using esketamine together with alcohol may increase side effects such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. You should avoid or limit the use of alcohol while being treated with esketamine. Nausea and vomiting may occur following the nasal application of esketamine. To help prevent nausea and vomiting, you should avoid eating for at least 2 hours before using esketamine and avoid drinking liquids for at least 30 minutes before using esketamine.

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Ask your doctor before using hyoscyamine together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking hyoscyamine. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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