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Drug Interaction Report

1 potential interaction and/or warning found for the following 2 drugs:

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Interactions between your drugs

Moderate

bismuth subsalicylate sarecycline

Applies to: Stress Maximum Strength (bismuth subsalicylate), sarecycline

ADJUST DOSING INTERVAL: Concomitant administration of bismuth-containing medications may impair the absorption of oral tetracyclines. The interaction has been studied with tetracycline and doxycycline. The proposed mechanism is chelation of tetracyclines by bismuth.

MANAGEMENT: Administration of a tetracycline and bismuth-containing preparation should either be avoided or separated by two to three hours. However, this precautionary measure is not considered necessary in treatment regimens where bismuth may be given in combination with tetracycline and other medications for the eradication of Helicobacter pylori infection, as the relative contribution of systemic versus local antimicrobial activity against Helicobacter pylori has not been established.

References (5)
  1. Ericsson CD, Feldman S, Pickering LK, Cleary TG (1982) "Influence of subsalicylate bismuth on absorption of doxycycline." JAMA, 247, p. 2266-7
  2. Albert KS, Welch RD, DeSante KA, DiSanto AR (1979) "Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture." J Pharm Sci, 68, p. 586-8
  3. (2018) "Product Information. Seysara (sarecycline)." Allergan Inc
  4. (2018) "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc.
  5. (2025) "Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN)." H2-Pharma LLC

Drug and food interactions

No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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