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Drug Interaction Report

1 potential interaction and/or warning found for the following 2 drugs:

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Interactions between your drugs

Minor

azaTHIOprine rapacuronium

Applies to: Azasan (azathioprine), Raplon (rapacuronium)

Limited data suggest that azathioprine may variously enhance, reduce, or reverse the effects of neuromuscular blockers. The mechanism for enhancement of effects is unknown. The mechanism for reduction of effects may be related to inhibition of phosphodiesterase in motor nerve terminals. The clinical significance is unknown. Routine dose titration and standard monitoring of the patient are recommended.

References

  1. Dretchen KL, Norgenroth VH, Standaert FG, Walts LF (1976) "Azathioprine: effects on neuromuscular transmission." Anesthesiology, 45, p. 604-9
  2. Gramstad L (1987) "Atracurium, vecuronium and pancuronium in end-stage renal failure." Br J Anaesth, 59, p. 995-1003
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  4. Cerner Multum, Inc. "Australian Product Information."
  5. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
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Drug and food interactions

No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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