Drug Interaction Report

MONITOR: Coadministration at the same time as tecovirimat may reduce the immune response to the live smallpox vaccine (vaccinia virus), according to animal studies. Potential interactions between tecovirimat and vaccines have not been studied in humans. The clinical impact of this potential interaction is unknown.

MANAGEMENT: The potential for reduced immune response to the live smallpox vaccine should be monitored if coadministered with tecovirimat.

ADJUST DOSING INTERVAL: Food may increase the extent of tecovirimat absorption following oral administration. When the recommended oral dose of tecovirimat (600 mg every 12 hours) was administered with a meal (approximately 600 calories and 25 g of fat) in healthy adults weighing less than 120 kg, tecovirimat absorption increased by 39% relative to fasting.

MANAGEMENT: Oral tecovirimat should be taken within 30 minutes after a full meal containing moderate or high fat (approximately 600 calories and 25 g of fat) with 6 to 8 ounces of water.