Drug Interaction Report

Using givinostat together with ranolazine may increase the risk of experiencing a change in the electrical activity of your heart called QT prolongation, which may result in irregular heartbeats that can be life-threatening. You might be more susceptible to this risk if you have heart problems or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting, which are commonly reported as side effects of givinostat treatment). Your doctor may be able to prescribe alternatives that do not interact, or you may need more frequent monitoring of your electrocardiogram to safely use both medications. You should seek immediate medical attention if you experience an irregular heartbeat or feel dizzy, lightheaded, or faint during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

You may take ranolazine with or without food, but should try to take it the same way every time. Grapefruit and grapefruit juice should be avoided if possible. Grapefruit juice can increase the levels of ranolazine in your body. High blood levels of food can occasionally cause an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with ranolazine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food increases the absorption of givinostat. To ensure adequate blood levels of the medication, givinostat should be administered with food. Additionally, food can help mask the bitter taste of the oral suspension. Follow up with your healthcare professional if you have any additional questions.