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Drug Interaction Report

2 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

No drug ⬌ drug interactions were found between the drugs in your list. However, this does not necessarily mean no drug interactions exist. Always consult your healthcare provider.

Drug and food interactions

Moderate

Prussian blue food

Applies to: Radiogardase (prussian blue)

ADJUST DOSING INTERVAL: Food may enhance the effectiveness of Prussian blue insoluble by stimulating bile production and enterohepatic circulation, which increases the amount of cesium and thallium in the gastrointestinal lumen for binding with Prussian blue followed by elimination in the feces.

MONITOR: Prussian blue insoluble acts by ion exchange, adsorption, and mechanical trapping within its crystal structure. Theoretically, it may bind some orally administered therapeutic drugs.

MANAGEMENT: Prussian blue insoluble may be taken with food to stimulate excretion of cesium or thallium. As appropriate, blood levels of concomitantly administered oral medications and/or clinical response should be monitored, and the dosages adjusted as necessary.

References (1)
  1. (2022) "Product Information. Radiogardase (Prussian blue)." Heyl Chemisch Pharmaceuticals
Minor

caffeine food

Applies to: Wakespan (caffeine)

The effect of grapefruit juice on the pharmacologic activity of caffeine is controversial. One report suggests that grapefruit juice increases the effect of caffeine. The proposed mechanism is inhibition of cytochrome P-450 metabolism of caffeine. However, a well-conducted pharmacokinetic/pharmacodynamic study did not demonstrate this effect. The clinical significance of this potential interaction is unknown.

References (2)
  1. (1995) "Grapefruit juice interactions with drugs." Med Lett Drugs Ther, 37, p. 73-4
  2. Maish WA, Hampton EM, Whitsett TL, Shepard JD, Lovallo WR (1996) "Influence of grapefruit juice on caffeine pharmacokinetics and pharmacodynamics." Pharmacotherapy, 16, p. 1046-52

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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