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Drug Interaction Report

2 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

procainamide thallous chloride Tl-201

Applies to: Pronestyl (procainamide), thallous chloride, tl-201

MONITOR: Coadministration of certain drugs may alter the myocardial uptake of thallous chloride Tl-201 and interfere with results of myocardial imaging studies. Drugs that increase or decrease coronary blood flow or potassium uptake may alter the biodistribution of thallous chloride Tl-201. Use of these drugs with thallous chloride TI-201 during imaging studies may result in a decrease in the number and size of perfusion defects, the appearance of false myocardial defects, and a decrease in myocardial localization and an increase in liver localization.

MANAGEMENT: Clinicians should be aware of possible diagnostic interference by these drugs.

References (3)
  1. Cerner Multum, Inc. "Australian Product Information."
  2. (2022) "Product Information. Thallous Chloride Tl 201 (thallous chloride Tl-201)." GE Healthcare
  3. Nuclear Pharmacy Website. University of Arkansas for Medical Sciences. College of Pharmacy (2015) Drug - Radiopharmaceutical Interactions. http://nuclearpharmacy.uams.edu/nicki.html#tl

Drug and food interactions

Minor

procainamide food

Applies to: Pronestyl (procainamide)

Ethanol may increase the acetylation of procainamide. Subtherapeutic plasma levels of procainamide may result in some patients. Because the acetylated metabolite of procainamide also possesses antiarrhythmic properties, the clinical effects are unclear.

References (1)
  1. Olsen H, Morland J (1982) "Ethanol-induced increase in procainamide acetylation in man." Br J Clin Pharmacol, 13, p. 203-8

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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