Drug Interaction Report
4 potential interactions and/or warnings found for the following 2 drugs:
- Kaletra (lopinavir / ritonavir)
- rifabutin
Interactions between your drugs
rifabutin ritonavir
Applies to: rifabutin, Kaletra (lopinavir / ritonavir)
Ritonavir may significantly increase the blood levels of rifabutin. This may increase the risk of serious side effects including low white blood cell count and an eye condition known as uveitis, which causes inflammation and swelling of the middle layer of the eye and can lead to blindness. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the interaction, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
rifabutin lopinavir
Applies to: rifabutin, Kaletra (lopinavir / ritonavir)
Rifabutin may reduce the blood levels of lopinavir, which may make the medication less effective in treating HIV infection. Contact your doctor if your condition worsens or you develop new infections during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
ritonavir food
Applies to: Kaletra (lopinavir / ritonavir)
Ritonavir should be taken with food to lessen gastrointestinal side effects. It is important that you take this medication exactly as prescribed by your doctor. Do not change your treatment or stop treatment without first talking to your doctor.
lopinavir food
Applies to: Kaletra (lopinavir / ritonavir)
Food may affect the absorption of lopinavir-ritonavir (brand name Kaletra) depending on whether you are taking the oral solution or the tablet. The oral solution should be taken with food to enhance absorption and help it work better. The tablet formulation can be take with or without food. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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