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Drug Interaction Report

2 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

cholera vaccine interferon gamma-1b

Applies to: cholera vaccine, Actimmune (interferon gamma-1b)

GENERALLY AVOID: The concomitant administration of interferon gamma with vaccines may theoretically increase the risk of an exaggerated immune response. The exact mechanism is unknown, but believed to be related to interferon gamma's immunomodulatory effects.

MANAGEMENT: The manufacturer recommends avoiding concomitant use with vaccines.

References (3)
  1. (2021) "Product Information. Imukin (interferon gamma-1b)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 4.0
  2. (2021) "Product Information. Actimmune (interferon gamma-1b)." Horizon Therapeutics USA Inc
  3. (2022) "Product Information. Immukin (interferon gamma-1b)." Clinigen Healthcare Ltd

Drug and food interactions

Moderate

cholera vaccine food

Applies to: cholera vaccine

ADJUST DOSING INTERVAL: Coadministration of oral cholera vaccine with food or an oral beverage may impair its efficacy. The formulations of both the inactivated and live, attenuated oral cholera vaccines (Dukoral and Vaxchora, respectively) are acid-labile, and must be administered with a buffer. According to the manufacturer, eating and drinking may interfere with the protective effect of the buffer. However, clinical data are not available.

MANAGEMENT: It is recommended that patients avoid eating or drinking for 60 minutes before and after administration of either Dukoral or Vaxchora oral cholera vaccines.

References (4)
  1. (2023) "Product Information. Vaxchora (cholera vaccine, live)." Patientric Ltd
  2. (2022) "Product Information. Dukoral (cholera vaccine, inactivated)." Valneva Sweden AB
  3. (2023) "Product Information. Dukoral (cholera vaccine)." Valneva UK Ltd
  4. (2024) "Product Information. Vaxchora (cholera vaccine, live)." Emergent Travel Health, Inc

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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