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Piperacillin and Tazobactam Injection

Last Updated: July 5, 2018
Status: Current

Products Affected - Description
    • Zosyn powder for solution for injection, Pfizer, 2.25 gram, vial, 10 count, NDC 00206-8852-16
    • Zosyn powder for solution for injection, Pfizer, 3.375 gram, vial, 10 count, NDC 00206-8854-16
    • Zosyn powder for solution for injection, Pfizer, 4.5 gram, vial, 10 count, NDC 00206-8855-16
    • Zosyn powder for solution for injection, Pfizer, 40.5 gram, bulk vial, 1 count, NDC 00206-8859-10
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 3.375 gram, ADD-Vantage vial, 10 count, NDC 00409-3378-13
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 4.5 gram, ADD-Vantage vial, 10 count, NDC 00409-3379-04
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 2.25 gram, vial, 10 count, NDC 00781-3110-95
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 3.375 gram, vial, 10 count, NDC 00781-3350-95
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 4.5 gram, vial, 10 count, NDC 00781-3367-95
Reason for the Shortage
    • Apotex temporarily discontinued piperacillin/tazobactam in April 2018.
    • AuroMedics and Sandoz could not provide a reason for the shortage.
    • Fresenius Kabi had piperacillin/tazobactam on shortage due to increased demand.
    • Mylan Institutional launched piperacillin/tazobactam 3.375 gram and 4.5 gram vials in early-June 2016.
    • Pfizer has Zosyn single dose vials and piperacillin/tazobactam on shortage due to manufacturing delays.
    • Sagent had piperacillin/tazobactam on shortage due to increased demand.
    • Sandoz has piperacillin/tazobactam available.
    • WG Critical Care states the reason for the shortage is increased demand.
    • FDA in conjunction with SteriMax was allowing temporary importation of piperacillin/tazobactam 3.375 gram, 4.5 gram, and 40.5 gram vials from Canada. This was being distributed through X-Gen Pharmaceuticals. These are no longer being imported with the launch of the products from X-Gen. The product codes on these items will not be recognized by U.S. systems so institutions will need to implement alternative plans to assure the dose is being given correctly. More information can be found on the FDA site at: https://www.fda.gov/downloads/Drugs/DrugSafety/DrugShortages/UCM543149.pdf.
    • Wockhardt has piperacillin/tazobactam injection available.
    • X-Gen has piperacillin/tazobactam injection available.
Available Products
    • Zosyn solution for injection, Baxter, 2.25 gram, 50 mL frozen premixed bag, 24 count, NDC 00206-8860-02
    • Zosyn solution for injection, Baxter, 3.375 gram, 50 mL frozen premixed bag, 24 count, NDC 00206-8861-02
    • Zosyn solution for injection, Baxter, 4.5 gram, 50 mL frozen premixed bag, 12 count, NDC 00206-8862-02
    • Piperacillin and Tazobactam powder for solution for injection, AuroMedics, 2.25 gram, vial, 10 count, NDC 55150-0119-30
    • Piperacillin and Tazobactam powder for solution for injection, AuroMedics, 3.375 gram, vial, 10 count, NDC 55150-0120-30
    • Piperacillin and Tazobactam powder for solution for injection, AuroMedics, 4.5 gram, vial, 10 count, NDC 55150-0121-50
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 2.25 gram, vial, 10 count, NDC 63323-0309-20
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 3.375 gram, vial, 10 count, NDC 63323-0300-30
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 4.5 gram, vial, 10 count, NDC 63323-0320-50
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 40.5 gram, bulk vial, 1 count, NDC 63323-0304-74
    • Piperacillin and Tazobactam powder for solution for injection, Mylan Institutional, 3.375 gram, vial, 10 count, NDC 67457-0522-37
    • Piperacillin and Tazobactam powder for solution for injection, Mylan Institutional, 4.5 gram, vial, 10 count, NDC 67457-0523-45
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 13.5 gram, vial, 1 count, NDC 00409-2999-14
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 2.25 gram, vial, 10 count, NDC 00409-3383-02
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 2.25 gram, ADD-Vantage vial, 10 count, NDC 00409-3374-02
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 3.375 gram, vial, 10 count, NDC 00409-3385-13
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 4.5 gram, vial, 10 count, NDC 00409-3390-04
    • Piperacillin and Tazobactam powder for solution for injection, Sagent, 2.25 gram, vial, 10 count, NDC 25021-0164-30
    • Piperacillin and Tazobactam powder for solution for injection, Sagent, 3.375 gram, vial, 10 count, NDC 25021-0165-30
    • Piperacillin and Tazobactam powder for solution for injection, Sagent, 4.5 gram, vial, 10 count, NDC 25021-0166-48
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 2.25 gram, vial, 10 count, NDC 00781-3344-95
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 3.375 gram, vial, 10 count, NDC 00781-3113-95
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 4.5 gram, vial, 10 count, NDC 00781-3114-95
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 2.25 gram, vial, 10 count, NDC 44567-0801-10
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 3.375 gram, vial, 10 count, NDC 44567-0802-10
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 4.5 gram, vial, 10 count, NDC 44567-0803-10
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 40.5 gram, bulk vial, 1 count, NDC 44567-0804-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 2.25 gram, vial, 10 count, NDC 64679-0034-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 3.375 gram, vial, 10 count, NDC 64679-0056-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 4.5 gram, vial, 10 count, NDC 64679-0012-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 40.5 gram, vial, 10 count, NDC 64679-0679-01
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 2.25 gram, vial, 10 count, NDC 39822-0123-02
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 3.375 gram, vial, 10 count, NDC 39822-0125-04
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 4.5 gram, vial, 10 count, NDC 39822-0127-06
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 40.5 gram, vial, 1 count, NDC 39822-0139-07

Estimated Resupply Dates

    • Apotex has temporarily discontinued all piperacillin/tazobactam presentations.
    • Pfizer has Zosyn 2.25 gram vials, 3.375 gram vials, 4.5 gram vials, and 40.5 gram vials on back order and the company estimates a release date of 2019. Pfizer has piperacillin/tazobactam 3.375 gram and 4.5 gram ADD-Vantage vials available in limited supply.

Updated

Updated July 5, 2018 by Megan Dryer, PharmD. Created February 5, 2014 by Leslie Jensen, PharmD, Drug Information Specialist. Copyright 2018, Drug Information Service, University of Utah, Salt Lake City, UT.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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