Paclitaxel Injection Shortage
Last Updated: March 3, 2025
Status: Current
Products Affected - Description
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- Paclitaxel intravenous solution for injection, Pfizer, 300 mg/50 mL (6 mg/mL) multiple dose vial, NDC 61703-0342-50
- Paclitaxel intravenous solution for injection, Teva, 100 mg/16.7 mL (6 mg/mL) multiple dose vial, NDC 00703-3216-01
- Paclitaxel intravenous solution for injection, Teva, 300 mg/50 mL (6 mg/mL) multiple dose vial, NDC 00703-3218-01
Reason for the Shortage
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- Almaject has discontinued paclitaxel injection.
- Fresenius Kabi has paclitaxel injection available.
- Pfizer has paclitaxel injection on shortage due to manufacturing delays.
- Sagent has paclitaxel injection available.
- Teva did not provide a reason for the shortage.
Available Products
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- Paclitaxel intravenous solution for injection, Fresenius Kabi, 100 mg/16.7 mL (6 mg/mL) multiple dose vial, NDC 63323-0763-16
- Paclitaxel intravenous solution for injection, Fresenius Kabi, 300 mg/50 mL (6 mg/mL) multiple dose vial, NDC 63323-0763-50
- Paclitaxel intravenous solution for injection, Pfizer, 100 mg/16.7 mL (6 mg/mL) multiple dose vial, NDC 61703-0342-22
- Paclitaxel intravenous solution for injection, Pfizer, 30 mg/5 mL (6 mg/mL) multiple dose vial, NDC 61703-0342-09
- Paclitaxel intravenous solution for injection, Sagent, 100 mg/16.7 mL (6 mg/mL) multiple dose vial, NDC 25021-0255-17
- Paclitaxel intravenous solution for injection, Sagent, 30 mg/5 mL (6 mg/mL) multiple dose vial, NDC 25021-0255-05
- Paclitaxel intravenous solution for injection, Sagent, 300 mg/50 mL (6 mg/mL) multiple dose vial, NDC 25021-0255-50
- Paclitaxel intravenous solution for injection, Teva, 150 mg/25 mL (6 mg/mL) multiple dose vial, NDC 00703-3217-01
- Paclitaxel intravenous solution for injection, Teva, 30 mg/5 mL (6 mg/mL) multiple dose vial, NDC 00703-3213-01
Estimated Resupply Dates
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- Pfizer has paclitaxel 300 mg/50 mL vials available in limited supply.
- Teva has paclitaxel 100 mg/16.7 mL vials on back order and the company estimates a release date of July 2025. The 300 mg/50 mL vials are on allocation.
Alternative Agents & Management
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- Consider evaluating the health-care system's total supply of paclitaxel before beginning patients on combination chemotherapy regimens containing paclitaxel. If adequate supplies are not available, select an alternative regimen.
- The choice of an alternative agent must be patient-specific and based on renal function, liver function, and the neoplasm type and location. No single agent can be substituted for paclitaxel.
- Consult a Hematology/Oncology specialist for patient- and neoplasm-specific recommendations.
- Refer to the ASHP Guidelines on Managing Drug Product Shortages for more guidance on developing a multidisciplinary plan when the supply must be allocated. https://www.ashp.org/-/media/assets/policy-guidelines/docs/guidelines/managing-drug-product-shortages.pdf
- Refer to national guidelines such as those from the National Comprehensive Cancer Network (www.nccn.org) or American Society of Clinical Oncology (http://www.asco.org/) for additional information regarding therapeutic use.
Updated
Updated March 3, 2025 by Michelle Wheeler, PharmD, Drug Information Specialist. Created October 31, 2022 by Leslie Jensen, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.
Further information
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