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Ofloxacin Ophthalmic Solution Shortage

Last Updated: July 19, 2024
Status: Current

Products Affected - Description
    • Ofloxacin ophthalmic solution, Bausch Health, 10 mL bottle, 1 count, NDC 24208-0434-10
    • Ofloxacin ophthalmic solution, Bausch Health, 5 mL bottle, 1 count, NDC 24208-0434-05
Reason for the Shortage
    • AbbVie has Ocuflox available.
    • Akorn ceased operations in February 2023.
    • Apotex has ofloxacin ophthalmic solution available.
    • Bausch Health did not provide a reason for the shortage.
    • Rising has ofloxacin ophthalmic solution available.
    • Sandoz discontinued ofloxacin ophthalmic solution.
Available Products
    • Ocuflox ophthalmic solution, Allergan (AbbVie), 5 mL bottle, 1 count, NDC 11980-0779-05
    • Ofloxacin ophthalmic solution, Apotex, 10 mL bottle, 1 count, NDC 60505-0560-01
    • Ofloxacin ophthalmic solution, Apotex, 5 mL bottle, 1 count, NDC 60505-0560-00
    • Ofloxacin ophthalmic solution, Rising Pharmaceuticals, 10 mL bottle, 1 count, NDC 64980-0515-01
    • Ofloxacin ophthalmic solution, Rising Pharmaceuticals, 5 mL bottle, 1 count, NDC 64980-0515-05

Estimated Resupply Dates

    • Bausch Health has ofloxacin ophthalmic solution in 5 mL and 10 mL bottles on back order and the company estimates a release date of July 2024.

Implications for Patient Care

    • Ofloxacin ophthalmic solution is a fluorinated carboxyquinolone antibiotic used to treat bacterial conjunctivitis and corneal ulcers in pediatric and adult patients.[1]

Alternative Agents & Management

    • The American Academy of Ophthalmology (AAO) recommends selecting the least expensive broad-spectrum ophthalmic antibiotic for a 5-7 day treatment strategy for bacterial conjunctivitis. No clinical evidence supports any antibiotic over another.[2]
    • For corneal ulcers (bacterial keratitis), AAO recommends an ophthalmic fluoroquinolone (ciprofloxacin 0.3%, ofloxacin 0.3%, and levofloxacin 1.5%) as empiric treatment to cover most bacteria.[3]

References

    1. DailyMed - Ofloxacin ophthalmic solution. Accessed July 17, 2024. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fe564e33-8f5d-4b57-87a9-7afae02eaf97.
    2. Cheung AY, Choi DS, Ahmad S, et al. Conjunctivitis Preferred Practice Pattern. Ophthalmology. 2024;131(4):P134-P204. doi:10.1016/j.ophtha.2023.12.0373.
    3. Rhee MK, Ahmad S, Amescua G, et al. Bacterial Keratitis Preferred Practice Pattern®. Ophthalmology. 2024;131(4):P87-P133. doi:10.1016/j.ophtha.2023.12.035.

Updated

Updated July 19, 2024 by Michelle Wheeler, PharmD, Drug Information Specialist. Created December 22, 2022 by Michelle Wheeler, PharmD, Drug Information Specialist. © 2024, Drug Information Service, University of Utah, Salt Lake City, UT.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.