Ofloxacin Ophthalmic Solution Shortage
Last Updated: February 3, 2025
Status: Current
Reason for the Shortage
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- AbbVie has Ocuflox available.
- Akorn ceased operations in February 2023.
- Apotex has ofloxacin ophthalmic solution available.
- Bausch Health has ofloxacin ophthalmic solution available.
- Rising has ofloxacin ophthalmic solution available.
- Sandoz discontinued ofloxacin ophthalmic solution.
Available Products
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- Ocuflox ophthalmic solution, Allergan (AbbVie), 5 mL bottle, 1 count, NDC 11980-0779-05
- Ofloxacin ophthalmic solution, Apotex, 10 mL bottle, 1 count, NDC 60505-0560-01
- Ofloxacin ophthalmic solution, Apotex, 5 mL bottle, 1 count, NDC 60505-0560-00
- Ofloxacin ophthalmic solution, Bausch Health, 10 mL bottle, 1 count, NDC 24208-0434-10
- Ofloxacin ophthalmic solution, Bausch Health, 5 mL bottle, 1 count, NDC 24208-0434-05
- Ofloxacin ophthalmic solution, Rising Pharmaceuticals, 10 mL bottle, 1 count, NDC 64980-0515-01
- Ofloxacin ophthalmic solution, Rising Pharmaceuticals, 5 mL bottle, 1 count, NDC 64980-0515-05
Implications for Patient Care
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- Ofloxacin ophthalmic solution is a fluorinated carboxyquinolone antibiotic used to treat bacterial conjunctivitis and corneal ulcers in pediatric and adult patients.[1]
Alternative Agents & Management
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- The American Academy of Ophthalmology (AAO) recommends selecting the least expensive broad-spectrum ophthalmic antibiotic for a 5-7 day treatment strategy for bacterial conjunctivitis. No clinical evidence supports any antibiotic over another.[2]
- For corneal ulcers (bacterial keratitis), AAO recommends an ophthalmic fluoroquinolone (ciprofloxacin 0.3%, ofloxacin 0.3%, and levofloxacin 1.5%) as empiric treatment to cover most bacteria.[3]
References
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- DailyMed - Ofloxacin ophthalmic solution. Accessed July 17, 2024. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fe564e33-8f5d-4b57-87a9-7afae02eaf97.
- Cheung AY, Choi DS, Ahmad S, et al. Conjunctivitis Preferred Practice Pattern. Ophthalmology. 2024;131(4):P134-P204. doi:10.1016/j.ophtha.2023.12.0373.
- Rhee MK, Ahmad S, Amescua G, et al. Bacterial Keratitis Preferred Practice Pattern®. Ophthalmology. 2024;131(4):P87-P133. doi:10.1016/j.ophtha.2023.12.035.
Updated
Updated February 3, 2025 by Leslie Jensen, PharmD, Drug Information Specialist. Created December 22, 2022 by Michelle Wheeler, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.
Further information
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