Multiple Electrolytes Large Volume Solutions for Injection Shortage
Last Updated: March 20, 2019
Status: Resolved
Reason for the Shortage
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- Baxter has Plasma-Lyte 148 and Plasma-Lyte A presentations available.
- ICU Medical had Normosol-R presentations on back order due to manufacturing delays.
Available Products
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- Normosol-R solution for injection, ICU Medical, 1000 mL bag, NDC 00409-7967-09
- Normosol-R pH 7.4 solution for injection, ICU Medical, 1,000 mL bag, NDC 00409-7670-09
- Normosol-R pH 7.4 solution for injection, ICU Medical, 500 mL bag, NDC 00409-7670-03
- Plasma-Lyte 148 solution for injection, Baxter, 1,000 mL bag, NDC 00338-0179-04
- Plasma-Lyte 148 solution for injection, Baxter, 500 mL bag, NDC 00338-0179-03
- Plasma-Lyte A solution for injection, Baxter, 1,000 mL bag, NDC 00338-0221-04
- Plasma-Lyte A solution for injection, Baxter, 500 mL bag, NDC 00338-0221-03
Alternative Agents & Management
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Table 1. Comparison of Multiple Electrolytes Large Volume Solutions for Injection1-4 Plasma-Lyte 148
Plasma-Lyte-A
(nonpyrogenic, isotonic)Normosol-R Contents (per 100 mL) Sodium chloride - 526 mg
Sodium gluconate - 502 mg
Sodium acetate trihydrate - 368 mg
Potassium chloride - 37 mg
Magnesium chloride - 30 mgSodium chloride - 526 mg
Sodium gluconate - 502 mg
Sodium acetate - 222 mg
Potassium chloride - 37 mg
Magnesium chloride, hexahydrate - 30 mgIonic concentrations (per 1 L) Sodium - 140 mEq
Potassium - 5 mEq
Magnesium - 3 mEq
Chloride - 98 mEq
Acetate - 27 mEq
Gluconate - 23 mEqSodium - 140 mEq
Potassium - 5 mEq
Magnesium - 3 mEq
Chloride - 98 mEq
Acetate - 27 mEq
Gluconate - 23 mEqOsmolarity 294 mOsmol/L 294 - 295 mOsmol/L pH 5.5 (Plasma-Lyte 148)
7.4 (Plasma-Lyte-A)6.6 (Normosol-R)
7.4 (Normosol-R pH 7.4)Caloric content 21 kcal/L Not specified in package insert Labeled indications Source of water and electrolytes
Alkalinizing agentReplacement of acute extracellular fluid volume losses in surgery, trauma, burns, or shock
Adjunct to restore decreased circulatory volume
References
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- Plasma-Lyte 148 [package insert]. Deerfield, IL: Baxter Healthcare; 2017.
- Plasma-Lyte A [package insert]. Deerfield, IL: Baxter Healthcare; 2017.
- Normosol-R [package insert]. Lake Forest, IL: Hospira; 2009.
- Normosol-R pH 7.4 [package insert]. Lake Forest, IL: Hospira; 2009.
Updated
Updated March 20, 2019 by Leslie Jensen, PharmD, Drug Information Specialist. Created February 1, 2018 by Elyse MacDonald, PharmD, MS, BCPS. © 2019, Drug Information Service, University of Utah, Salt Lake City, UT.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.