Methylprednisolone Acetate Injection

• • Depo-Medrol injection, Pfizer, 20 mg/mL, 5 mL multiple dose vial, 1 count, NDC 00009-0274-01
  • Depo-Medrol injection, Pfizer, 40 mg/mL, 5 mL multiple dose vial, 1 count, NDC 00009-0280-02
  • Depo-Medrol injection, Pfizer, 40 mg/mL, 5 mL multiple dose vial, 25 count, NDC 00009-0280-51
  • Depo-Medrol injection, Pfizer, 80 mg/mL, 1 mL single dose vial, 25 count, NDC 00009-3475-03
  • Methylprednisolone Acetate injection, Sagent, 40 mg/mL, 10 mL multiple dose vial, 1 count, NDC 25021-0820-10
  • Methylprednisolone Acetate injection, Sagent, 40 mg/mL, 5 mL multiple dose vial, 1 count, NDC 25021-0820-05
  • Methylprednisolone Acetate injection, Teva, 40 mg/mL, 1 mL single dose vial, 1 count, NDC 00703-0031-01
  • Methylprednisolone Acetate injection, Teva, 40 mg/mL, 1 mL single dose vial, 25 count, NDC 00703-0031-04
  • Methylprednisolone Acetate injection, Teva, 40 mg/mL, 10 mL multiple dose vial, 1 count, NDC 00703-0045-01
  • Methylprednisolone Acetate injection, Teva, 40 mg/mL, 5 mL multiple dose vial, 1 count, NDC 00703-0043-01
  • Methylprednisolone Acetate injection, Teva, 80 mg/mL, 1 mL single dose vial, 1 count, NDC 00703-0051-01
  • Methylprednisolone Acetate injection, Teva, 80 mg/mL, 1 mL single dose vial, 25 count, NDC 00703-0051-04
  • Methylprednisolone Acetate injection, Teva, 80 mg/mL, 5 mL multiple dose vial, 1 count, NDC 00703-0063-01

• • Amneal is actively shipping allocated methylprednisolone acetate single dose vials on historical demand.[1]
  • Pfizer has Depo-Medrol on shortage due to increased demand and manufacturing delays.[2]
  • Sagent has methylprednisolone acetate injection available.[3]
  • Teva did not provide a reason for the shortage.[4]

• • Depo-Medrol injection, Pfizer, 40 mg/mL, 1 mL single dose vial, 1 count, NDC 00009-3073-01
  • Depo-Medrol injection, Pfizer, 40 mg/mL, 1 mL single dose vial, 25 count, NDC 00009-3073-03
  • Depo-Medrol injection, Pfizer, 40 mg/mL, 10 mL multiple dose vial, 1 count, NDC 00009-0280-03
  • Depo-Medrol injection, Pfizer, 40 mg/mL, 10 mL multiple dose vial, 25 count, NDC 00009-0280-52
  • Depo-Medrol injection, Pfizer, 80 mg/mL, 1 mL single dose vial, 1 count, NDC 00009-3475-01
  • Depo-Medrol injection, Pfizer, 80 mg/mL, 5 mL multiple dose vial, 1 count, NDC 00009-0306-02
  • Depo-Medrol injection, Pfizer, 80 mg/mL, 5 mL multiple dose vial, 25 count, NDC 00009-0306-12
  • Methylprednisolone Acetate injection, Amneal, 40 mg/mL, 1 mL single dose vial, 1 count, NDC 70121-1573-01
  • Methylprednisolone Acetate injection, Amneal, 40 mg/mL, 1 mL single dose vial, 25 count, NDC 70121-1573-05
  • Methylprednisolone Acetate injection, Amneal, 80 mg/mL, 1 mL single dose vial, 1 count, NDC 70121-1574-01
  • Methylprednisolone Acetate injection, Amneal, 80 mg/mL, 1 mL single dose vial, 25 count, NDC 70121-1574-05
  • Methylprednisolone Acetate injection, Sagent, 80 mg/mL, 5 mL multiple dose vial, 1 count, NDC 25021-0821-05

Estimated Resupply Dates

• • Sagent has methylprednisolone acetate 40 mg/mL 1 mL and 5 mL vials on allocation.
  • Teva has all presentations of methylprednisolone acetate on back order and the company cannot estimate a release date.
  • Pfizer has Depo-Medrol 20 mg/mL 5 mL vials in 1 count on back order and the company estimates a release date of December 2022. The 40 mg/mL 5 mL vials in 1 count and 25 count are on back order with an estimated release date of January 2023 for the 1 count and December 2022 for the 25 count. The 80 mg/mL 1 mL vials in 25 count are available in limited supply.

Alternative Agents & Management

• • The table below lists possible alternatives for patients who receive injectable corticosteroid suspensions.

  Table 1. Alternative agents for disorders commonly treated injectable corticosteroid suspensions.5-6

  Intra-articular injections for disorders such as rheumatoid arthritis and bursitis	Betamethasone acetate/betamethasone sodium phosphate
  Intralesional injections	Triamcinolone acetonide <40 mg per treatment Methylprednisolone acetate 20 to 40 mg per treatment for large lesions

  
  

References

• 1. Amneal (personal communication). August 20, and December 16 and 17, 2021, and August 26, 2022.
  2. Pfizer (personal communication). August 20, September 17, November 19, December 10, 2021, and July 1 and August 26, 2022.
  3. Sagent (personal communication. July 22 and August 26, 2022.
  4. Teva (personal communication). August 20, September 17, November 12, December 10, 2021, and July 1 and August 26, 2022.
  5. Lexicomp Online. Hudson, OH: Wolters Kluwer Clinical Drug Information, Inc; 2018.
  6. Dexamethasone sodium phosphate injection [package insert]. Lake Zurich, IL: Fresenius Kabi; 2021.