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Leucovorin Calcium Injection Shortage

Last Updated: May 20, 2025
Status: Current

Products Affected - Description
    • Leucovorin Calcium lyophilized powder for injection, Hikma, 50 mg, vial, 1 count, NDC 00143-9555-01
    • Leucovorin Calcium lyophilized powder for solution for injection, Hikma, 350 mg, vial, 1 count, NDC 00143-9552-01
    • Leucovorin Calcium lyophilized powder for injection, Sagent, 500 mg, vial, 1 count, NDC 25021-0828-50
Reason for the Shortage
    • Fresenius Kabi has leucovorin injection available.
    • Hikma has leucovorin on shortage due to increased demand.
    • Meitheal has leucovorin injection available.
    • Sagent has leucovorin on shortage due to increased demand.
    • Teva has discontinued leucovorin injection.
    • Viatris had leucovorin injection available.
    • Slate Run Pharmaceuticals has leucovorin injection available.
Available Products
    • Leucovorin Calcium injection, Fresenius Kabi, 10 mg/mL, 10 mL vial, 1 count, NDC 63323-0631-10
    • Leucovorin Calcium injection, Fresenius Kabi, 10 mg/mL, 50 mL vial, 1 count, NDC 63323-0631-50
    • Leucovorin Calcium lyophilized powder for solution for injection, Fresenius Kabi, 500 mg, vial, 1 count, NDC 63323-0711-00
    • Leucovorin Calcium, Fresenius Kabi, 200 mg, vial, 1 count, NDC 63323-0710-50
    • Leucovorin Calcium lyophilized powder for injection, Hikma, 100 mg, vial, 1 count, NDC 00143-9554-01
    • Leucovorin Calcium lyophilized powder for injection, Hikma, 200 mg, vial, 1 count, NDC 00143-9553-01
    • Leucovorin Calcium, Meitheal Pharmaceuticals, 100 mg, vial, 1 count, NDC 71288-0161-20
    • Leucovorin Calcium, Meitheal Pharmaceuticals, 200 mg, vial, 1 count, NDC 71288-0162-30
    • Leucovorin Calcium, Meitheal Pharmaceuticals, 350 mg, vial, 1 count, NDC 71288-0163-30
    • Leucovorin Calcium, Meitheal Pharmaceuticals, 50 mg, vial, 1 count, NDC 71288-0160-10
    • Leucovorin Calcium, Meitheal Pharmaceuticals, 500 mg, vial, 1 count, NDC 71288-0164-50
    • Leucovorin Calcium lyophilized powder for injection, Mylan Institutional (Viatris), 200 mg, vial, 1 count, NDC 67457-0529-20
    • Leucovorin Calcium lyophilized powder for injection, Mylan Institutional (Viatris), 350 mg, vial, 1 count, NDC 67457-0530-35
    • Leucovorin Calcium lyophilized powder for injection, Mylan Institutional (Viatris), 50 mg, vial, 1 count, NDC 67457-0528-10
    • Leucovorin Calcium lyophilized powder for injection, Sagent, 100 mg, vial, 10 count, NDC 25021-0814-30
    • Leucovorin Calcium lyophilized powder for injection, Sagent, 200 mg, vial, 1 count, NDC 25021-0815-30
    • Leucovorin Calcium lyophilized powder for injection, Sagent, 350 mg, vial, 1 count, NDC 25021-0816-30
    • Leucovorin Calcium lyophilized powder for solution for injection, Sagent, 50 mg, vial, 10 count, NDC 25021-0813-10
    • Leucovorin Calcium, Slate Run Pharmaceuticals, 100 mg, vial, 1 count, NDC 70436-0117-80
    • Leucovorin Calcium, Slate Run Pharmaceuticals, 200 mg, vial, 1 count, NDC 70436-0118-80
    • Leucovorin Calcium, Slate Run Pharmaceuticals, 350 mg, vial, 1 count, NDC 70436-0119-80
    • Leucovorin Calcium, Slate Run Pharmaceuticals, 50 mg, vial, 10 count, NDC 70436-0116-82
    • Leucovorin Calcium, Slate Run Pharmaceuticals, 500 mg, vial, 1 count, NDC 70436-0120-80

Estimated Resupply Dates

    • Hikma has leucovorin 50 mg and 350 mg vials on back order and the company estimates a release date of late-June to early-July 2025 for the 50 mg vials and late-May 2025 for the 350 mg vials.
    • Sagent has leucovorin 500 mg vials on back order and the company cannot estimate a release date.

Updated

Updated May 20, 2025 by Michelle Wheeler, PharmD, Drug Information Specialist. Created June 6, 2010 by Jane Chandramouli, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.

Further information

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