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Hydromorphone Immediate-Release Oral Presentations Shortage

Last Updated: August 1, 2025
Status: Current

Products Affected - Description
    • Dilaudid oral immediate release tablet, Rhodes, 2 mg, bottle, 100 count, NDC 42858-0122-01
    • Dilaudid oral immediate release tablet, Rhodes, 4 mg, bottle, 100 count, NDC 42858-0234-01
    • Dilaudid oral immediate release tablet, Rhodes, 4 mg, bottle, 500 count, NDC 42858-0234-50
    • Dilaudid oral immediate release tablet, Rhodes, 8 mg, bottle, 100 count, NDC 42858-0338-01
    • Dilaudid oral solution, Rhodes, 1 mg/mL, 473 mL bottle, NDC 42858-0416-16
    • Hydromorphone Hydrochloride oral solution, Hikma, 1 mg/mL, 473 mL bottle, NDC 00054-0386-63
    • Hydromorphone Hydrochloride oral immediate release tablet, Rhodes, 2 mg, unit-dose blister pack, 100 count, NDC 42858-0301-25
    • Hydromorphone Hydrochloride oral immediate release tablet, Rhodes, 4 mg, bottle, 500 count, NDC 42858-0302-50
    • Hydromorphone Hydrochloride oral immediate release tablet, Rhodes, 4 mg, unit-dose blister pack, 100 count, NDC 42858-0302-25
Reason for the Shortage
    • Hikma did not provide a reason for the shortage.
    • Mallinckrodt refuses to provide availability information.
    • Rhodes did not provide a reason for the shortage.
Available Products
    • Hydromorphone Hydrochloride oral immediate release tablet, Rhodes, 2 mg, bottle, 100 count, NDC 42858-0301-01
    • Hydromorphone Hydrochloride oral immediate release tablet, Rhodes, 4 mg, bottle, 100 count, NDC 42858-0302-01
    • Hydromorphone Hydrochloride oral immediate release tablet, Rhodes, 8 mg, bottle, 100 count, NDC 42858-0303-01
    • Hydromorphone Hydrochloride oral solution, Rhodes, 1 mg/mL, 473 mL bottle, NDC 42858-0304-16

Estimated Resupply Dates

    • Hikma has hydromorphone 1 mg/mL oral solution on allocation.
    • Rhodes has hydromorphone 2 mg and 4 mg tablets in unit-dose packaging and hydromorphone 4 mg tablets in 500 count bottles on back order and the company cannot estimate a release date.
    • Rhodes has Dilaudid 2 mg tablets in 100 count bottles, 4 mg tablets in 500 count bottles, and 1 mg/mL oral solution on back order and the company cannot estimate a release date. Dilaudid 4 mg tablets in 100 count bottles and 8 mg tablets in 100 count bottles are available in limited quantities.

Updated

Updated August 1, 2025 by Leslie Jensen, PharmD, Drug Information Specialist. Created December 15, 2023 by Leslie Jensen, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.

Further information

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