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Heparin Injection

Last Updated: November 28, 2018
Status: Current

Products Affected - Description
    • Heparin Sodium solution for injection, Fresenius Kabi, 10,000 unit/mL, 0.5 mL preservative-free vial, 25 count, NDC 63323-0543-02
    • Heparin Sodium solution for injection, Fresenius Kabi, 10,000 unit/mL, 4 mL multiple dose vial, 25 count, NDC 63323-0459-09
    • Heparin Sodium solution for injection, Hikma, 1,000 unit/mL, 30 mL multiple dose vial, 25 count, NDC 00641-2450-55
    • Heparin Sodium solution for injection, Hikma, 5,000 unit/mL, 1 mL single dose vial, 25 count, NDC 00641-0400-12
    • Heparin Sodium solution for injection, Hikma, 5,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 00641-2460-55
    • Heparin Sodium solution for injection, Pfizer, 1,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 00409-2720-02
    • Heparin Sodium solution for injection, Pfizer, 1,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 00069-0058-01
    • Heparin Sodium solution for injection, Pfizer, 1,000 unit/mL, 2 mL single dose vial, 25 count, NDC 00069-0043-01
    • Heparin Sodium solution for injection, Pfizer, 1,000 unit/mL, 30 mL multiple dose vial, 10 count, NDC 00069-0137-03
    • Heparin Sodium solution for injection, Pfizer, 1,000 unit/mL, 30 mL multiple dose vial, 25 count, NDC 00409-2720-03
    • Heparin Sodium solution for injection, Pfizer, 10,000 unit/mL, 0.5 mL preservative-free Carpuject syringe, 50 count, NDC 00409-1316-32
    • Heparin Sodium solution for injection, Pfizer, 10,000 unit/mL, 1 mL multiple dose vial, 25 count, NDC 00069-0062-01
    • Heparin Sodium solution for injection, Pfizer, 10,000 unit/mL, 1mL single dose vial, 25 count, NDC 00409-2721-01
    • Heparin Sodium solution for injection, Pfizer, 5,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 00409-2723-02
    • Heparin Sodium solution for injection, Pfizer, 5,000 unit/mL, 1mL Carpuject syringe, 50 count, NDC 00409-1402-12
    • Heparin Sodium solution for injection, Pfizer, 5,000 unit/mL, 1mL single dose vial, 25 count, NDC 00409-2723-01
    • Heparin Sodium solution for injection, Sagent, 1,000 unit/mL, 2 mL single dose vial, 25 count, NDC 25021-0401-02
    • Heparin Sodium solution for injection, Sagent, 10,000 unit/mL, 1 mL vial, 25 count, NDC 25021-0403-01
    • Heparin Sodium solution for injection, Sagent, 5,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 25021-0402-10
Reason for the Shortage
    • Fresenius Kabi has heparin on shortage due to increased demand.
    • Hikma did not provide a reason for the shortage.
    • Mylan has heparin presentations available.
    • Pfizer did not provide a reason for the shortage.
    • Sagent did not provide a reason for the shortage.
Available Products
    • Heparin Sodium solution for injection, Fresenius Kabi, 1,000 unit/mL, 1 mL multiple dose vial, 25 count, NDC 63323-0540-01
    • Heparin Sodium solution for injection, Fresenius Kabi, 1,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 63323-0540-11
    • Heparin Sodium solution for injection, Fresenius Kabi, 1,000 unit/mL, 2 mL single dose vial, 25 count, NDC 63323-0276-02
    • Heparin Sodium solution for injection, Fresenius Kabi, 1,000 unit/mL, 30 mL multiple dose vial, 25 count, NDC 63323-0540-31
    • Heparin Sodium solution for injection, Fresenius Kabi, 10,000 unit/mL, 1 mL multiple dose vial, 25 count, NDC 63323-0542-01
    • Heparin Sodium solution for injection, Fresenius Kabi, 10,000 unit/mL, 5 mL multiple dose vial, 25 count, NDC 63323-0542-07
    • Heparin Sodium solution for injection, Fresenius Kabi, 20,000 unit/mL, 1 mL multiple dose vial, 25 count, NDC 63323-0915-01
    • Heparin Sodium solution for injection, Fresenius Kabi, 5,000 unit/mL, 1 mL multiple dose vial, 25 count, NDC 63323-0262-01
    • Heparin Sodium solution for injection, Fresenius Kabi, 5,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 63323-0047-10
    • Heparin Sodium solution for injection, Hikma, 1,000 unit/mL, 1 mL single dose vial, 25 count, NDC 00641-0391-12
    • Heparin Sodium solution for injection, Hikma, 10,000 unit/mL, 1 mL single dose vial, 25 count, NDC 00641-0410-12
    • Heparin Sodium solution for injection, Mylan, 1,000 unit/mL, 1 mL multiple dose vial, 25 count, NDC 67457-0372-99
    • Heparin Sodium solution for injection, Mylan, 1,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 67457-0385-99
    • Heparin Sodium solution for injection, Mylan, 1,000 unit/mL, 30 mL multiple dose vial, 25 count, NDC 67457-0384-99
    • Heparin Sodium solution for injection, Mylan, 10,000 unit/mL, 1 mL multiple dose vial, 25 count, NDC 67457-0602-99
    • Heparin Sodium solution for injection, Mylan, 10,000 unit/mL, 4 mL multiple dose vial, 25 count, NDC 67457-0603-99
    • Heparin Sodium solution for injection, Mylan, 20,000 unit/mL, 1 mL multiple dose vial, 25 count, NDC 67457-0373-99
    • Heparin Sodium solution for injection, Mylan, 5,000 unit/mL, 1 mL multiple dose vial, 25 count, NDC 67457-0374-99
    • Heparin Sodium solution for injection, Mylan, 5,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 67457-0383-99
    • Heparin Sodium solution for injection, Pfizer, 1,000 unit/500 mL in 0.9% Sodium Chloride, premixed bag, 18 count, NDC 00409-7620-03
    • Heparin Sodium solution for injection, Pfizer, 1,000 unit/mL, 1 mL single dose vial, 25 count, NDC 00409-2720-01
    • Heparin Sodium solution for injection, Pfizer, 5,000 unit/mL, 1 mL multiple dose vial, 25 count, NDC 00069-0059-03
    • Heparin Sodium solution for injection, Pfizer, 5,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 00069-0059-01
    • Heparin Sodium solution for injection, Sagent, 1,000 unit/mL, 1 mL vial, 25 count, NDC 25021-0400-01
    • Heparin Sodium solution for injection, Sagent, 1,000 unit/mL, 10 mL multiple dose vial, 25 count, NDC 25021-0400-10
    • Heparin Sodium solution for injection, Sagent, 1,000 unit/mL, 30 mL multiple dose vial, 25 count, NDC 25021-0400-30
    • Heparin Sodium solution for injection, Sagent, 10,000 unit/mL, 4 mL multiple dose vial, 25 count, NDC 25021-0403-04
    • Heparin Sodium solution for injection, Sagent, 20,000 unit/mL, 1mL multiple dose vial, 25 count, NDC 25021-0404-01
    • Heparin Sodium solution for injection, Sagent, 5,000 unit/mL, 1 mL vial, 25 count, NDC 25021-0402-01

Estimated Resupply Dates

    • Fresenius Kabi has heparin 10,000 unit/mL 0.5 mL preservative-free vials on back order and the company estimates a release date in mid- to late-December 2018. The 10,000 unit/mL 4 mL vials are available as short-dated product (<4 months expiration date).
    • Hikma has 1,000 unit/mL 30 mL vials and 5,000 unit/mL 10 mL vials on back order and the company cannot estimate a release date. The 5,000 unit/mL 2 mL vials are on back order and the company estimates a release date in December 2018.
    • Pfizer has 5,000 unit/mL 1 mL Carpuject syringes on back order and the company estimates a release date of 4th quarter 2019. The 1,000 unit/mL 10 mL and 30 mL vials, 5,000 unit/mL 10 mL multidose vials, and 10,000 unit/mL 1 mL vials are on back order and the company cannot estimate a release date. The 5,000 unit/mL 1 mL glass vials are on back order and the company estimates a release date in December 2018. The 10,000 unit/mL 0.5 mL carpuject syringes and 10,000 unit/mL 1 mL glass vials are available in limited supply.
    • Sagent has 1,000 unit/mL 2 mL vials on back order and the company estimates a release date in December 2018. The 5,000 unit/mL 10 mL vials and 10,000 unit/mL 1 mL vials are on back order and the company cannot estimate a release date.

Safety

    • Pfizer has sent a safety information letter about certain lots of heparin injection and other medications supplied in Carpuject syringes. There is a potential for particulates and cracked needle hubs.
    • Special instructions are described in this letter including doing visual inspection for cracks and particulate matter and using a 5 micron filter for administration. The details of the special handling instructions and affected lot numbers are available at https://www.pfizerinjectablessupply.com/sites/default/files/carpuject_specific_lot_handling_instructions.pdf.

Updated

Updated November 28, 2018 by Leslie Jensen, PharmD, Drug Information Specialist. Created October 13, 2017 by Leslie Jensen, PharmD, Drug Information Specialist. Copyright 2018, Drug Information Service, University of Utah, Salt Lake City, UT.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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