Eptifibatide Injection Shortage
Last Updated: March 14, 2025
Status: Current
Products Affected - Description
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- Eptifibatide injection, Amneal, 0.75 mg/mL, 100 mL vial, 1 count, NDC 70121-1003-01
- Eptifibatide injection, Amneal, 2 mg/mL, 10 mL vial, 1 count, NDC 70121-1002-01
- Eptifibatide injection, Eugia US, 0.75 mg/mL, 100 mL vial, 1 count, NDC 55150-0218-99
- Eptifibatide injection, Eugia US, 2 mg/mL, 100 mL vial, 1 count, NDC 55150-0220-99
- Eptifibatide injection, Sagent, 0.75 mg/mL, 100 mL vial, 1 count, NDC 70860-0305-51 - discontinued
- Eptifibatide injection, Sagent, 2 mg/mL, 10 mL vial, 1 count, NDC 25021-0409-10 - discontinued
Reason for the Shortage
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- Accord has temporarily discontinued eptifibatide injection.
- Amneal did not provide a reason for the shortage.
- Avenacy has eptifibatide injection available.
- Baxter has eptifibatide injection available.
- Eugia did not provide a reason for the shortage.
- Merck discontinued Integrilin in October 2020. Wholesalers may continue to sell inventory until product expires.
- Viatris has eptifibatide injection available.
- Sagent states the shortage was due to manufacturing delay.
- Slate Run has eptifibatide injection available.
Available Products
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- Eptifibatide injection, Baxter, 0.75 mg/mL, 100 mL vial, 1 count, NDC 00338-9558-10
- Eptifibatide injection, Eugia US, 2 mg/mL, 10 mL vial, 1 count, NDC 55150-0219-10
- Eptifibatide injection, Mylan Institutional (Viatris), 0.75 mg/mL, 100 mL vial, 1 count, NDC 67457-0631-10
- Eptifibatide injection, Mylan Institutional (Viatris), 2 mg/mL, 10 mL vial, 1 count, NDC 67457-0629-10
- Eptifibatide injection, Mylan Institutional (Viatris), 2 mg/mL, 100 mL vial, 1 count, NDC 67457-0630-10
- Eptifibatide injection, Sagent, 0.75 mg/mL, 100 mL vial, 1 count, NDC 25021-0408-51
- Eptifibatide injection, Slate Run Pharmaceuticals, 0.75 mg/mL, 100 mL vial, 1 count, NDC 70436-0027-80
- Eptifibatide injection, Slate Run Pharmaceuticals, 2 mg/mL, 10 mL vial, 1 count, NDC 70436-0026-80
Estimated Resupply Dates
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- Amneal has eptifibatide 0.75 mg/mL 100 mL vials and 2 mg/mL in 10 mL vials on long-term back order and the company cannot estimate a release date.
- Eugia has all eptifibatide 2 mg/mL 100 mL vials and 0.75 mg/mL 100 mL vials presentations on intermittent back order and the company is releasing supplies as they become available.
Implications for Patient Care
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- Eptifibatide is an FDA-approved glycoprotein IIb/IIIa antagonist to be used in adult patients for treatment of acute coronary syndrome (unstable angina/NSTEMI) and/or undergoing percutaneous coronary intervention.
- According to the 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes, glycoprotein IIb/IIIa antagonists can be administered to patients with NSTE-ACS and high-risk features, who are either not adequately pretreated with clopidogrel/ticagrelor or treated with UFH and adequately pretreated with clopidogrel at the time of PCI.
- According to the 2021 ACC/AHA/SCAI Clinical Practice Guideline for Coronary Artery Revascularization, glycoprotein IIb/IIIa antagonists are generally reserved for patients with a high thrombus burden or no-reflow or slow flow that is attributable to distal embolization of thrombus as an adjunct therapy to dual antiplatelet therapy (DAPT).
- Intravenous glycoprotein IIb/IIIa inhibitors are not recommended in patients with stable ischemic heart diseases (SIHD) undergoing PCI (no benefit in reducing ischemic events or mortality). Other glycoproteins IIb/IIIa inhibitors are tirofiban and abciximab. However, abciximab is discontinued in the United States
Alternative Agents & Management
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- Tirofiban - guidelines recommend a glycoprotein IIb/IIIa inhibitor and do not specify one agent over another.
References
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- 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. https://www.ahajournals.org/doi/epub/10.1161/CIR.0000000000001038
- 2014 AHA/ACC Guideline for the Management of Patients With Non-ST-Elevation Acute Coronary Syndromes https://www.ahajournals.org/doi/10.1161/cir.0000000000000134#sec-4
- Aggrastat. [package insert] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e850111f-e713-41a2-9c65-21c517cf5511
Updated
Updated March 14, 2025 by Leslie Jensen, PharmD, Drug Information Specialist. Created May 21, 2020 by Leslie Jensen, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.
Further information
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