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Ephedrine Injection Shortage

Last Updated: August 19, 2025
Status: Current

Products Affected - Description
    • Ephedrine injection, Hikma, 5 mg/mL, 5 mL syringe, 10 count, NDC 00641-6236-10
    • Ephedrine injection, Sagent, 50 mg/mL, 1 mL vial, 25 count, NDC 25021-0836-01
Reason for the Shortage
    • Dr. Reddy's has ephedrine injection available.
    • Endo has ephedrine injection available.
    • Exela has Avokaz injection available.
    • Hikma did not provide a reason for the shortage.
    • Nexus has ephedrine injection available.
    • Sagent did not provide a reason for the shortage.
    • Sandoz has ephedrine injection available.
    • Somerset has ephedrine injection available.
Available Products
    • Akovaz injection, Exela Pharma Sciences, 5 mg/mL, 5 mL syringe, 10 count, NDC 51754-4250-03
    • Akovaz injection, Exela Pharma Sciences, 50 mg/mL, 1 mL vial, 25 count, NDC 51754-4200-24
    • Emerphed injection, Nexus Pharmaceuticals, 5 mg/mL, 10 mL syringe, 10 count, NDC 14789-0251-10
    • Emerphed injection, Nexus Pharmaceuticals, 5 mg/mL, 10 mL vial, 10 count, NDC 14789-0250-10
    • Emerphed injection, Nexus Pharmaceuticals, 5 mg/mL, 5 mL syringe, 10 count, NDC 14789-0252-10
    • Ephedrine injection, Dr. Reddy's, 50 mg/mL, 1 mL vial, 25 count, NDC 43598-0735-25
    • Ephedrine injection, Endo Pharmaceuticals, 5 mg/mL, 10 mL vial, 10 count, NDC 42023-0243-01
    • Ephedrine injection, Endo Pharmaceuticals, 50 mg/mL, 1 mL vial, 25 count, NDC 42023-0216-25
    • Ephedrine injection, Hikma, 50 mg/mL, 1 mL vial, 25 count, NDC 00641-6238-25
    • Ephedrine injection, Sandoz, 50 mg/mL, 1 mL vial, 25 count, NDC 00781-3269-95
    • Ephedrine injection, Somerset Therapeutics LLC, 50 mg/mL, 1 mL vial, 10 count, NDC 70069-0819-10

Estimated Resupply Dates

    • Hikma has ephedrine 5 mg/mL 5 mL syringes on back order and the company estimates a release date of early- to mid-September 2025.
    • Sagent has short-dated ephedrine 50 mg/mL 1 mL vials available with an expiration date of February 2026.

Updated

Updated August 19, 2025 by Michelle Wheeler, PharmD, Drug Information Specialist. Created April 21, 2025 by Michelle Wheeler, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.