Dopamine Hydrochloride Injection Shortage
Last Updated: January 8, 2025
Status: Current
Products Affected - Description
-
- Dopamine Hydrochloride injection, Hikma, 40 mg/mL, 5 mL vial, 25 count, NDC 00143-9252-25
- Dopamine Hydrochloride in 5% Dextrose injection, Pfizer, 400 mg/250 mL, LifeCare flexible container 12 count, NDC 00409-7809-22
- Dopamine Hydrochloride in 5% Dextrose injection, Pfizer, 800 mg/500 mL, LifeCare flexible container 12 count, NDC 00409-7809-24
Reason for the Shortage
-
- Baxter has dopamine available.
- Hikma did not provide a reason for the shortage.
- Pfizer has dopamine on shortage due to manufacturing delays.
Available Products
-
- Dopamine Hydrochloride injection, Hikma, 40 mg/mL, 10 mL vial, 25 count, NDC 00143-9254-25
- Dopamine Hydrochloride injection, Pfizer, 40 mg/mL, 10 mL vial, 25 count, NDC 00409-9104-20
- Dopamine Hydrochloride injection, Pfizer, 40 mg/mL, 5 mL vial, 25 count, NDC 00409-5820-01
- Dopamine Hydrochloride in 5% Dextrose injection, Baxter, 200 mg/250 mL, Viaflex Plus Plastic container 18 count, NDC 00338-1005-02
- Dopamine Hydrochloride in 5% Dextrose injection, Baxter, 400 mg/250 mL, Viaflex Plus Plastic container 18 count, NDC 00338-1007-02
- Dopamine Hydrochloride in 5% Dextrose injection, Baxter, 400 mg/500 mL, Viaflex Plus Plastic container 12 count, NDC 00338-1005-03
- Dopamine Hydrochloride in 5% Dextrose injection, Baxter, 800 mg/250 mL, Viaflex Plus Plastic container 18 count, NDC 00338-1009-02
- Dopamine Hydrochloride in 5% Dextrose injection, Baxter, 800 mg/500 mL, Viaflex Plus Plastic container 12 count, NDC 00338-1007-03
- Dopamine Hydrochloride in 5% Dextrose injection, Pfizer, 800 mg/250 mL, LifeCare flexible container 12 count, NDC 00409-7810-22
Estimated Resupply Dates
-
- Hikma has dopamine 40 mg/mL 5 mL vials on back order and the company estimates a release date of late-February 2025.
- Pfizer has dopamine 800 mg/500 mL premixed bags on back order and the company estimates a release date of October 2025. The 400 mg/250 mL premixed bags are available in limited supply.
Implications for Patient Care
-
- Dopamine is a natural catecholamine that at higher doses (5-15 mcg/kg/min) exhibits inotropic effects and increased cardiac output for patients hemodynamically unstable (eg, cardiogenic shock).[1-3]
Safety
-
- Premixed bags and vial strength may differ than our standard concentrations. Ensure proper dosing/rate of administration if non-standard concentration is used.¯¯
Alternative Agents & Management
-
- For states of hemodynamic instability, use alternative catecholamine or non-catecholamine inotropes and vasopressors.[4]
- Information on assessing the management of different types of cardiogenic shock can be found at https://www.ahajournals.org/doi/10.1161/CIR.0000000000000525#d1e1478. Table 5 serves as a good reference for which vasoactive agents to use in specific causes/presentations of cardiogenic shock.[4]
- The American College of Cardiology created a guidance of recommendations for the DOBUTamine shortage (another inotropic agent). Table 1 provides a summary of pharmacological properties of all vasopressors and inotropes that can also be utilized to assess alterative agents for DOPamine. This information can be found here: https://www.acc.org/Latest-in-Cardiology/Articles/2022/08/02/12/42/What-You-Need-to-Know-Guidance-For-Clinicians-on-Dobutamine-Shortage
References
-
- Dopamine HCl in 5% Dextorse injection [prescribing information]. Mukilteo, WA: HF Acquisition Co LLC; February 2023.
- Dopamine HCL injection [prescribing information]. Lake Forest, IL: Hospira Inc; September 2023.
- Dopamine. Lexicomp Online, Lexi-Drugs. UpToDate, Inc, Waltham, MA; 2023.¯
- van Diepen S, Katz JN, Albert NM, et al. Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association. Circulation. 2017;136(16):e232-e268. doi:10.1161/CIR.0000000000000525
Updated
Updated January 8, 2025 by Michelle Wheeler, PharmD, Drug Information Specialist. Created March 9, 2022 by Michelle Wheeler, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.