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Dopamine Hydrochloride Injection Shortage

Last Updated: January 23, 2024
Status: Current

Products Affected - Description
    • Dopamine Hydrochloride injection, Hikma, 40 mg/mL, 5 mL vial, 25 count, NDC 00143-9252-25
    • Dopamine Hydrochloride in 5% Dextrose injection, Baxter, 200 mg/250 mL, Viaflex Plus Plastic container 18 count, NDC 00338-1005-02
    • Dopamine Hydrochloride in 5% Dextrose injection, Baxter, 400 mg/250 mL, Viaflex Plus Plastic container 18 count, NDC 00338-1007-02
    • Dopamine Hydrochloride in 5% Dextrose injection, Baxter, 400 mg/500 mL, Viaflex Plus Plastic container 12 count, NDC 00338-1005-03
    • Dopamine Hydrochloride in 5% Dextrose injection, Baxter, 800 mg/250 mL, Viaflex Plus Plastic container 18 count, NDC 00338-1009-02
    • Dopamine Hydrochloride in 5% Dextrose injection, Baxter, 800 mg/500 mL, Viaflex Plus Plastic container 12 count, NDC 00338-1007-03
    • Dopamine Hydrochloride in 5% Dextrose injection, Pfizer, 400 mg/250 mL, LifeCare flexible container 12 count, NDC 00409-7809-22
    • Dopamine Hydrochloride in 5% Dextrose injection, Pfizer, 800 mg/250 mL, LifeCare flexible container 12 count, NDC 00409-7810-22
    • Dopamine Hydrochloride in 5% Dextrose injection, Pfizer, 800 mg/500 mL, LifeCare flexible container 12 count, NDC 00409-7809-24
Reason for the Shortage
    • Baxter has dopamine on a protective allocation due to potential for increased demand.
    • Hikma did not provide a reason for the shortage.
    • Pfizer has dopamine on shortage due to manufacturing delays.
Available Products
    • Dopamine Hydrochloride injection, Hikma, 40 mg/mL, 10 mL vial, 25 count, NDC 00143-9254-25
    • Dopamine Hydrochloride injection, Pfizer, 40 mg/mL, 10 mL vial, 25 count, NDC 00409-9104-20
    • Dopamine Hydrochloride injection, Pfizer, 40 mg/mL, 5 mL vial, 25 count, NDC 00409-5820-01

Estimated Resupply Dates

    • Baxter has all presentations on a protective allocation.
    • Pfizer has dopamine 400 mg/250 mL premixed bags on back order and the company estimates a release date of February 2024. The 800 mg/250 mL premixed bags are on back order and the company estimates a release date of April 2024. The 800 mg/500 mL premixed bags are on back order and the company estimates a release date of May 2024.
    • Hikma has dopamine 40 mg/mL 5 mL vials on back order and the company estimates a release date of late-January to early-February 2024.

Implications for Patient Care

    • Dopamine is a natural catecholamine that at higher doses (5-15 mcg/kg/min) exhibits inotropic effects and increased cardiac output for patients hemodynamically unstable (eg, cardiogenic shock).[1-3]

Safety

    • Premixed bags and vial strength may differ than our standard concentrations. Ensure proper dosing/rate of administration if non-standard concentration is used.⿯⿯

Alternative Agents & Management

    • For states of hemodynamic instability, use alternative catecholamine or non-catecholamine inotropes and vasopressors.[4]
    • Information on assessing the management of different types of cardiogenic shock can be found at https://www.ahajournals.org/doi/10.1161/CIR.0000000000000525#d1e1478. Table 5 serves as a good reference for which vasoactive agents to use in specific causes/presentations of cardiogenic shock.[4]
    • The American College of Cardiology created a guidance of recommendations for the DOBUTamine shortage (another inotropic agent). Table 1 provides a summary of pharmacological properties of all vasopressors and inotropes that can also be utilized to assess alterative agents for DOPamine. This information can be found here: https://www.acc.org/Latest-in-Cardiology/Articles/2022/08/02/12/42/What-You-Need-to-Know-Guidance-For-Clinicians-on-Dobutamine-Shortage

References

    1. Dopamine HCl in 5% Dextorse injection [prescribing information]. Mukilteo, WA: HF Acquisition Co LLC; February 2023.
    2. Dopamine HCL injection [prescribing information]. Lake Forest, IL: Hospira Inc; September 2023.
    3. Dopamine. Lexicomp Online, Lexi-Drugs. UpToDate, Inc, Waltham, MA; 2023.⿯
    4. van Diepen S, Katz JN, Albert NM, et al. Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association. Circulation. 2017;136(16):e232-e268. doi:10.1161/CIR.0000000000000525

Updated

Updated January 23, 2024 by Michelle Wheeler, PharmD, Drug Information Specialist. Created March 9, 2022 by Michelle Wheeler, PharmD, Drug Information Specialist. © 2024, Drug Information Service, University of Utah, Salt Lake City, UT.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.