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Desmopressin Acetate Nasal Spray

Last Updated: December 13, 2022
Status: Current

Products Affected - Description
    • DDAVP nasal spray, Ferring, 10 mcg/0.1 mL, 5 mL bottle, NDC 55566-2500-00
    • Stimate nasal spray, Ferring, 150 mcg/0.1 mL, 2.5 mL bottle, NDC 00053-6871-00
    • Desmopressin Acetate nasal spray, Amring Pharmaceuticals, 10 mcg/0.1 mL, 5 mL bottle, NDC 69918-0501-05 - discontinued
Reason for the Shortage
    • In August 2020, Ferring recalled DDAVP nasal spray, desmopressin nasal spray, and Stimate nasal spray due to higher desmopressin amounts than specified. Additional information is available at https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/ferring-us-issues-voluntary-nationwide-recall-ddavpr-nasal-spray-10-mcg01ml-desmopressin-acetate#:~:text=Ferring%20Pharmaceuticals%20US%20is%20voluntarily,below%20to%20the%20consumer%20level.
    • Amring has discontinued desmopressin nasal spray.
    • Apotex has desmopressin nasal spray available.
    • Bausch Health has desmopressin acetate nasal spray available.
    • Sun Pharma has desmopressin acetate nasal spray available.
    • Zydus has desmopressin nasal spray available.
Available Products
    • Desmopressin Acetate nasal spray, Apotex, 10 mcg/0.1 mL, 5 mL bottle, NDC 60505-0815-00
    • Desmopressin Acetate nasal spray, Bausch Health, 10 mcg/0.1 mL, 5 mL bottle, NDC 24208-0342-05
    • Desmopressin Acetate nasal spray, Sun Pharma, 10 mcg/0.1 mL, 5 mL bottle, NDC 47335-0788-91
    • Desmopressin Acetate nasal spray, Zydus, 10 mcg/0.1 mL, 5 mL bottle, NDC 68382-0384-01

Estimated Resupply Dates

    • Ferring has Stimate nasal spray on back order and the company cannot estimate a release date.
    • Ferring has DDAVP nasal spray on back order and the company cannot estimate a release date.

Implications for Patient Care

    • Stimate contains a higher concentration of desmopressin per spray (150 mcg/actuation) than other desmopressin nasal spray products. It is approved for use in hemophilia A and in mild to moderate Type I von Willebrand's disease with Factor VIII levels greater than 5%.[1]
    • Desmopressin nasal spray 10 mcg/actuation is labeled for use as antidiuretic replacement therapy in the management of central diabetes insipidus in adults and children 4 years of age and older.[1]

References

    1. Desmopressin. Lexi-Drugs Online. Hudson, OH: Lexi-Comp Inc; 2020.

Updated

Updated December 13, 2022 by Leslie Jensen, PharmD, Drug Information Specialist. Created August 14, 2020 by Leslie Jensen, PharmD, Drug Information Specialist. © 2022, Drug Information Service, University of Utah, Salt Lake City, UT.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.