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Bupivacaine with Epinephrine Injection Shortage

Last Updated: May 2, 2025
Status: Current

Products Affected - Description
    • Bupivacaine (with epinephrine 1:200,000) injection, Pfizer, 0.25%, 10 mL vial, 50 count, NDC 00409-9042-01
    • Bupivacaine (with epinephrine 1:200,000) injection, Pfizer, 0.25%, 30 mL vial, 100 count, NDC 00409-9042-17
    • Bupivacaine (with epinephrine 1:200,000) injection, Pfizer, 0.25%, 50 mL vial, 25 count, NDC 00409-9043-01
    • Bupivacaine (with epinephrine 1:200,000) injection, Pfizer, 0.5%, 10 mL vial, 50 count, NDC 00409-9045-01
    • Bupivacaine (with epinephrine 1:200,000) injection, Pfizer, 0.5%, 30 mL vial, 100 count, NDC 00409-9045-17
    • Bupivacaine (with epinephrine 1:200,000) injection, Pfizer, 0.5%, 50 mL vial, 25 count, NDC 00409-9046-01
    • Sensorcaine-MPF (with epinephrine 1:200,000) injection, Fresenius Kabi, 0.25%, 10 mL vial, 25 count, NDC 63323-0468-17
    • Sensorcaine-MPF (with epinephrine 1:200,000) injection, Fresenius Kabi, 0.25%, 30 mL vial, 25 count, NDC 63323-0468-37
    • Sensorcaine-MPF (with epinephrine 1:200,000) injection, Fresenius Kabi, 0.5%, 10 mL vial, 25 count, NDC 63323-0462-17
    • Sensorcaine-MPF (with epinephrine 1:200,000) injection, Fresenius Kabi, 0.5%, 30 mL vial, 25 count, NDC 63323-0462-37
Reason for the Shortage
    • Fresenius Kabi has bupivacaine and epinephrine on shortage due to increased demand.
    • Pfizer has bupivacaine with epinephrine on shortage due to manufacturing delays.
Available Products
    • Marcaine (with epinephrine 1:200,000) injection, Pfizer, 0.25%, 10 mL vial, 10 count, NDC 00409-1746-10
    • Marcaine (with epinephrine 1:200,000) injection, Pfizer, 0.25%, 30 mL vial, 10 count, NDC 00409-1746-30
    • Marcaine (with epinephrine 1:200,000) injection, Pfizer, 0.25%, 50 mL vial, 1 count, NDC 00409-1752-50
    • Marcaine (with epinephrine 1:200,000) injection, Pfizer, 0.5%, 10 mL vial, 10 count, NDC 00409-1749-10
    • Marcaine (with epinephrine 1:200,000) injection, Pfizer, 0.5%, 30 mL vial, 10 count, NDC 00409-1749-29
    • Marcaine (with epinephrine 1:200,000) injection, Pfizer, 0.5%, 50 mL vial, 1 count, NDC 00409-1755-50
    • Sensorcaine (with epinephrine 1:200,000) injection, Fresenius Kabi, 0.25%, 50 mL vial, 25 count, NDC 63323-0461-57
    • Sensorcaine (with epinephrine 1:200,000) injection, Fresenius Kabi, 0.5%, 50 mL vial, 25 count, NDC 63323-0463-57
    • Sensorcaine-MPF (with epinephrine 1:200,000) injection, Fresenius Kabi, 0.75%, 30 mL vial, 25 count, NDC 63323-0460-37

Estimated Resupply Dates

    • Pfizer has 0.25% bupivacaine with epinephrine 10 mL and 30 mL preservative-free vials on back order and the company estimates a release date of December 2025. The 0.25% bupivacaine with epinephrine 50 mL vials are on back order and the company estimates a release date of December 2025. The 0.5% bupivacaine with epinephrine 10 mL and 30 mL preservative-free vials are on back order and the company estimates a release date of December 2025 for the 10 mL vials and February 2026 for the 30 mL vials. The 0.5% bupivacaine with epinephrine 50 mL vials are on back order and the company estimates a release date of December 2025.
    • Fresenius Kabi has short-dated 0.25% Sensorcaine 10 mL and 30 mL preservative-free vials available with an expiration date of < 7 months for the 10 mL vials and < 9 months for the 30 mL vials. There are short-dated 0.5% Sensorcaine 10 mL and 30 mL preservative-free vials available with an expiration date of < 7 months.

Updated

Updated May 2, 2025 by Michelle Wheeler, PharmD, Drug Information Specialist. Created September 2, 2016 by Michelle Wheeler, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.

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