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Asparaginase Erwinia Chrysanthemi

Last Updated: March 29, 2018
Status: Current

Asparaginase Erwinia Chrysanthemi

Reason for the Shortage
    • Jazz Pharmaceuticals has Erwinaze on shortage due to manufacturing issues.
Available Products
    • Erwinaze, Jazz Pharmaceuticals, 10,000 unit, 3 mL vial, 5 count, NDC 57902-0249-05

Estimated Resupply Dates

    • Jazz Pharmaceuticals has Erwinaze available. The company has a site where supply updates can be found and where clinicians can register to get updates emailed or texted. This is located at

Implications for Patient Care

    • Clinicians should contact Jazz Pharmaceuticals to let them know of patients being actively treated with Erwinaze.


    • Jazz Pharmaceuticals has sent Dear Health Care Provider letters regarding the administration of certain batches of Erwinaze (Batches 174K, 177K, 178K, 179K, 180K, 181K, 182K, 183K, 184K, 185ak, 186). Particulate matter was seen in vials from these batches during routine inspections. Jazz states that the product must be given intramuscularly only and NOT intravenously. Also, 5-micron filter needles are to be used when withdrawing Erwinaze from vials. The most recent letter with further details can be found at // and


Updated March 29, 2018 by Michelle Wheeler, PharmD, Drug Information Specialist. Created October 11, 2016 by Elyse MacDonald, PharmD, MS, BCPS. Copyright 2018, Drug Information Service, University of Utah, Salt Lake City, UT.