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Drug Interactions between tisotumab vedotin and tucatinib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

tucatinib tisotumab vedotin

Applies to: tucatinib and tisotumab vedotin

Tucatinib may increase the blood levels of the active medication in tisotumab vedotin. This may increase the risk and/or severity of side effects such as nausea; vomiting; diarrhea; loss of appetite; tingling, numbness or burning in the hands and feet; muscle weakness; hair loss; eye disorders (dry eyes, inflammation of the cornea, corneal ulcers, blurred vision, vision loss); bleeding; low red and white blood cell counts; and inflammation of the lungs. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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