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Drug Interactions between tipiracil / trifluridine and vandetanib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

vandetanib tipiracil

Applies to: vandetanib and tipiracil / trifluridine

Vandetanib may increase the blood levels and effects of tipiracil. You may need a dose adjustment if you have been receiving tipiracil and are starting treatment with vandetanib. Likewise, if you have been receiving both medications, the dose of tipiracil may need to be adjusted if vandetanib is discontinued. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

trifluridine food

Applies to: tipiracil / trifluridine

Trifluridine should be taken within one hour after eating your morning or evening meals. This may help to reduce the medication's harmful effects on white blood cells. Talk to you doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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