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Drug Interactions between SymPak II and tirzepatide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

phenylephrine pseudoephedrine

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine) and SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine)

Both phenylephrine and pseudoephedrine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

chlorpheniramine brompheniramine

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine) and SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine)

Using chlorpheniramine together with brompheniramine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

chlorpheniramine methscopolamine

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine) and SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine)

Using chlorpheniramine together with methscopolamine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylephrine methscopolamine

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine) and SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine)

Methscopolamine may increase the effects of phenylephrine on your blood pressure and heart rate. Before receiving these medications, you should let your doctor know if you have high blood pressure or heart disease. You may not be able to use one or both of these medications, or you may need closer monitoring by your doctor in order to use these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

brompheniramine methscopolamine

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine) and SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine)

Using brompheniramine together with methscopolamine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

chlorpheniramine tirzepatide

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine) and tirzepatide

Tirzepatide can cause an increase in heart rate and may have additive effects with other medications that can also increase heart rate such as chlorpheniramine. There are times when an elevated heart rate is appropriate, like when you are exercising. However, you should contact your doctor if you notice that your heart rate is high at other times for unknown reasons or if it is occurring frequently. Signs and symptoms of an elevated heart rate may include a sensation of a racing or pounding heartbeat, chest pain, shortness of breath, or a heart rate greater than 100 beats per minute in an adult. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylephrine tirzepatide

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine) and tirzepatide

Phenylephrine may interfere with blood glucose control and reduce the effectiveness of tirzepatide and other diabetic medications. Monitor your blood sugar levels closely. You may need a dose adjustment of your diabetic medications during and after treatment with phenylephrine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

pseudoephedrine tirzepatide

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine) and tirzepatide

Pseudoephedrine may interfere with blood glucose control and reduce the effectiveness of tirzepatide and other diabetic medications. Monitor your blood sugar levels closely. You may need a dose adjustment of your diabetic medications during and after treatment with pseudoephedrine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

brompheniramine tirzepatide

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine) and tirzepatide

Tirzepatide can cause an increase in heart rate and may have additive effects with other medications that can also increase heart rate such as brompheniramine. There are times when an elevated heart rate is appropriate, like when you are exercising. However, you should contact your doctor if you notice that your heart rate is high at other times for unknown reasons or if it is occurring frequently. Signs and symptoms of an elevated heart rate may include a sensation of a racing or pounding heartbeat, chest pain, shortness of breath, or a heart rate greater than 100 beats per minute in an adult. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

methscopolamine tirzepatide

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine) and tirzepatide

Tirzepatide can cause an increase in heart rate and may have additive effects with other medications that can also increase heart rate such as methscopolamine. There are times when an elevated heart rate is appropriate, like when you are exercising. However, you should contact your doctor if you notice that your heart rate is high at other times for unknown reasons or if it is occurring frequently. Signs and symptoms of an elevated heart rate may include a sensation of a racing or pounding heartbeat, chest pain, shortness of breath, or a heart rate greater than 100 beats per minute in an adult. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

chlorpheniramine food

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine)

Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with chlorpheniramine. Do not use more than the recommended dose of chlorpheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

brompheniramine food

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine)

Alcohol can increase the nervous system side effects of brompheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with brompheniramine. Do not use more than the recommended dose of brompheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

tirzepatide food

Applies to: tirzepatide

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases, this may affect how well and/or how fast those medications work, or it may make no difference. Talk to a healthcare provider if you have any questions or concerns, and contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

methscopolamine food

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine)

Ask your doctor before using methscopolamine together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking methscopolamine. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylephrine food

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine)

Both phenylephrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

pseudoephedrine food

Applies to: SymPak II (brompheniramine / chlorpheniramine / methscopolamine / phenylephrine / pseudoephedrine)

Both pseudoephedrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.