Drug Interactions between Sohonos and tretinoin
This report displays the potential drug interactions for the following 2 drugs:
- Sohonos (palovarotene)
- tretinoin
Interactions between your drugs
tretinoin palovarotene
Applies to: tretinoin and Sohonos (palovarotene)
Using tretinoin together with palovarotene is generally not recommended. Combining these medications may increase the risk of hypervitaminosis A, a condition that stems from excessive vitamin A-related effects. Potentially serious problems that could occur include vision impairment, increased pressure in the brain, high cholesterol/triglycerides, and inflammation of the liver, pancreas, or the rest of the digestive tract. Check your food and medicine labels to make sure you do not consume additional vitamin A in excess of the recommended daily allowance. Talk to your doctor or pharmacist if you are uncertain whether you are getting too much vitamin A. Early signs and symptoms of hypervitaminosis A include inflammation or bleeding of the gums or lips; dry, scaly, itchy, or red skin; hair loss; headache; dizziness; and nausea. You should seek immediate medical attention if you experience potential signs that could indicate increased pressure in the brain (headache, nausea, vomiting, visual disturbances) or liver damage (fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, yellowing of the skin or eyes). It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
palovarotene food
Applies to: Sohonos (palovarotene)
Grapefruit, pomelo, and juices or supplements containing these fruits may increase the blood levels of palovarotene, which may increase the risk and/or severity of side effects such as dry skin, dry lips, hair loss, skin rash, itching, skin and nail infection, dry eyes, night blindness, depression, and mood changes. It may also increase the risk of a rare, but potentially serious, condition called pseudotumor cerebri caused by increased pressure in the brain. Palovarotene should be taken with food at approximately the same time each day. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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