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Drug Interactions between sofpironium topical and Synalgos-DC

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

dihydrocodeine sofpironium topical

Applies to: Synalgos-DC (aspirin / caffeine / dihydrocodeine) and sofpironium topical

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of opioids with anticholinergic agents may result in additive central nervous system (CNS), gastrointestinal, and genitourinary effects. The risk and/or severity of adverse effects such as sedation, dizziness, confusion, cognitive and psychomotor impairment, dry mouth, constipation, and urinary retention may increase. Severe constipation may lead to paralytic ileus in some cases.

MANAGEMENT: Caution and close monitoring of central nervous system, gastrointestinal, and genitourinary adverse effects are recommended when opioids are used with anticholinergic agents. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Minor

aspirin caffeine

Applies to: Synalgos-DC (aspirin / caffeine / dihydrocodeine) and Synalgos-DC (aspirin / caffeine / dihydrocodeine)

Information for this minor interaction is available on the professional version.

Drug and food interactions

Moderate

aspirin food

Applies to: Synalgos-DC (aspirin / caffeine / dihydrocodeine)

Ask your doctor before using aspirin together with ethanol (alcohol). Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor

caffeine food

Applies to: Synalgos-DC (aspirin / caffeine / dihydrocodeine)

Information for this minor interaction is available on the professional version.

Minor

aspirin food

Applies to: Synalgos-DC (aspirin / caffeine / dihydrocodeine)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer