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Drug Interactions between sodium bicarbonate / tartaric acid and treosulfan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sodium bicarbonate treosulfan

Applies to: sodium bicarbonate / tartaric acid and treosulfan

Consumer information for this interaction is not currently available.

MONITOR: Parenteral hydration with sodium bicarbonate during treosulfan infusion has been related to an increase of skin disorders like rash and dermatitis. The mechanism of the interaction may be acceleration of the pH-dependent formation of alkylating epoxides. Also, this combination may induce bladder injury from activation of treosulfan in alkaline urine.

MANAGEMENT: Caution is advised when parenteral sodium bicarbonate is used during treosulfan infusion. Patients should be monitored for increased skin disorders such as rash and dermatitis, and for bladder injury. Some experts discourage the alkalinization of patients during treatment with treosulfan and recommend a split-dose or continuous IV infusion regimen of high-dose treosulfan to avoid risk of methanesulfonic acid induced acidosis.

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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