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Drug Interactions between Seroquel and Xenazine

This report displays the potential drug interactions for the following 2 drugs:

  • Seroquel (quetiapine)
  • Xenazine (tetrabenazine)

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Interactions between your drugs


QUEtiapine tetrabenazine

Applies to: Seroquel (quetiapine) and Xenazine (tetrabenazine)

Talk to your doctor before using tetrabenazine together with QUEtiapine. Combining these medications can increase the risk of an irregular heart rhythm that may be serious. In addition, tetrabenazine can increase the risk and severity of side effects associated with QUEtiapine, including Parkinson-like symptoms and abnormal muscle movements. The most serious of these movement disorders is a condition known as tardive dyskinesia (TD). TD mostly involves muscles in the face, but may also involve those in the limbs. You cannot control these movements, and they may not go away even after stopping the medication. There is no treatment for TD, but symptoms may lessen or disappear over time after stopping the medication. You may be more likely to develop TD if you are elderly, especially if you are a woman, or if you have diabetes. Your risk also increases the longer you take QUEtiapine and the more of it that you take. Let your doctor know promptly if you experience muscle spasm or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping. Other symptoms such as fever, heat intolerance, excessive sweating, stiffness, difficulty moving or swallowing, sudden dizziness, lightheadedness, fainting, and fast or pounding heartbeats should also be reported to your doctor. You should avoid activities requiring mental alertness such as driving or operating machinery until you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


tetrabenazine food

Applies to: Xenazine (tetrabenazine)

Alcohol can increase the nervous system side effects of tetrabenazine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with tetrabenazine. Do not use more than the recommended dose of tetrabenazine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.